血清抗—HBcIgM检测在乙型病毒性肝炎疫情监测中的应用  

Application of serum anti-HBc IgM in surveillance of hepatitis B virus

作　　者：孔祥钦 钟任扬 李艳华[1] 周荣群[1] 沈超华 陈青山[1] 张少忠[1] 黄远祥[1] 

机构地区：[1]五华县疾病预防控制中心,广东梅州514400

出　　处：《热带医学杂志》2017年第2期255-257,共3页Journal of Tropical Medicine

基　　金：梅州市科技计划项目(2013B159)

摘　　要：目的探讨血清抗-HBc IgM检测在乙型病毒性肝炎疫情监测中的应用,为提高病例报告准确性,为规范乙肝报告提供科学依据。方法 2013-2015年对五华县"法定传染病报告系统"中报告的乙肝病例中,"HBsAg阳性时间"报告为"既往未检测或结果不详"的病例进行血样采集,进行血清抗-HBc IgM 1∶1 000检测。同时收集2010-2012年乙肝疫情相关数据进行比较分析。结果 2010-2012年五华县乙肝急性、慢性分别占2.08%、96.49%,2013-2015年乙肝急性、慢性分别占11.53%、85.37%,2013-2015年的急性乙肝、慢性乙肝占比与2010-2012年比较,差异均有统计学意义(χ~2=51.23、53.78,均P<0.05);开展血清学抗-HBc IgM 1∶1000检测后,急性乙肝的比例明显上升,慢性乙肝的比例明显下降。结论乙肝的诊断报告需要进一步规范。血清抗-HBc IgM 1∶1 000检测可以提高诊断准确率,规范乙肝疫情报告。Objective In order to dicuss the application of serum anti-HBc IgM detection in the surveillance of hepatitis B epidemic situstion,improve the accuracy of case report and to provide scientific basis for standardizing hepatitis B report.Methods Among the hepatitis B cases reported in the NNDRS in Wuhua county in 2013- 2015,blood samples were collected from those cases indicated as＂not detected or unknown＂,for the detection of serological anti-HBC IgM.At the same time,the data of hepatitis B epidemic situation in 2010-2012 were collected and analyzed. Results From the reported system,the constitution of acute and chronic hepatitis B cases accounted for 2.08% and 96.49%,respectively,in Wuhua county in 2010-2012,and 11.53% and 85.37%,respectively,in 2013- 2015. After the detection of serological anti- HBC IgM,the constitution of acute hepatitis B increased significant,and chronic hepatitis B decreased significantly. Conclusions The diagnostic report of hepatitis B should be further standardized. Detection of serological anti-HBC IgM can improve the diagnostic accuracy and standardization of reporting hepatitis B.

关 键 词：乙型病毒性肝炎(乙肝) 抗-HBC IGM 监测 应用 

分 类 号：R512.62[医药卫生—内科学]