预注右旋美托咪啶用于喉显微手术麻醉的临床效果观察  

The Obeservation of Clinical effect of preemptive injection of dexmedetomidine for laryngeal microsurgery anesthesia

作　　者：孙守栈 李婷 

机构地区：[1]山东省青岛市第九人民医院麻醉科,266000 [2]山东省青岛市第九人民医院手术室,266000

出　　处：《临床合理用药杂志》2017年第8期17-19,共3页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的观察预注右旋美托咪啶用于喉显微手术麻醉的临床效果。方法选取医院接受喉显微手术治疗的患者58例,随机分为对照组和试验组,每组29例。对照组给予丙泊酚联合雷米芬太尼麻醉,试验组接受丙泊酚联合雷米芬太尼麻醉前预注右旋美托咪啶,对2组麻醉前(T0)、麻醉诱导后(T1)、手术开始5 min(T2)、手术结束时(T3)血流动力学与去甲肾上腺素(NE)、肾上腺素(E)的浓度进行统计,对2组丙泊酚用量,睁眼、手术、完全清醒、离开手术室及拔管时间进行比较,并观察不良反应发生情况。结果试验组T0、T1、T2、T3时MAP、HR值均低于对照组(P<0.01或P<0.05);试验组各时间点NE、E浓度均低于与对照组(P<0.01或P<0.05);试验组丙泊酚用量少于对照组,睁眼时间、手术时间、完全清醒时间、离开手术室时间及拔管时间均短于对照组(P均<0.01)。试验组不良反应发生率为13.79%,低于对照组的37.93%(P<0.05)。结论预注右旋美托咪啶用于喉显微手术麻醉的临床效果显著,安全性较高,值得临床进一步推广实施。Objective To investigate the clinical effect of preemptive injection of dexmedetomidine for laryngeal mi- erosurgery anesthesia. Methods Fifty-eight patients who received laryngeal microsurgery were randomly divided into control group and experimental group with each group of 29 cases. The control group was given propofol combined with remifentanil an- esthesia, and the experimental group received propofol combined with remifentanil anesthesia after the pre-injection of dexme- detomidine. The statistics of hemodynamies and norepinephrine, adrenaline concentration were recorded for the two group at the time of before anesthesia （ TO ）, anesthesia induction （ T1 ）, surgery began 5 min （ T2 ） and the end of surgery （ T3 ）. The propofol dosage and the time of open eyes, operation, complete awake, leaving the operating room and extubation were compared within the two group and observe the incidence of adverse reaction. Results The value of MAP, HR in experimental group at time TO ,T1 ,T2 and T3 were lower than these of control group（ P 〈 0.01 or P 〈 0.05 ）. The concentrations of NE and E in the experimental group at different point of time were lower than those in the control group （ P 〈 0.01 or P 〈 0.05 ）. The time of propofol was less than that of the control group, and the time of open eyes, operation, complete awake, leaving the operating room and extubation were all shorter than those of the control group （P 〈 0.01 ）. The incidence of adverse reactions in the test group was 13.79% ,which was lower than that of the control group 37.93 % （P 〈 0.05 ）. Conclusion The clinical effect of preemptive injection of dexmedetomidine for laryngeal microsurgery anesthesia is significant and safe, which is worth of further promotion to the public.

关 键 词：预注 右旋美托咪啶 喉显微手术 麻醉 

分 类 号：R614[医药卫生—麻醉学]