北京地区RhD阴性献血人群Rh血型研究  

Investigation of Rh phenotypes in Rh-negative individuals in Beijing

作　　者：闫芳[1] 张磊[1] 张烨[1] 刘素芳[1] 刘亚庆[1] 苗天红[1] YAN Fang ZHANG Lei ZHANG Ye LIU Sufang LIU Yaqing MIAO Tianhong.(Beijing Red Cross Blood Center, Beijing 100088, China.)

机构地区：[1]北京市红十字血液中心,北京100088

出　　处：《中国输血杂志》2017年第1期56-57,共2页Chinese Journal of Blood Transfusion

摘　　要：目的研究北京地区RhD阴性献血人群中Rh表型的分布情况及不同表型与D变异型的相关性。方法用间接抗球方法(IAT)确认检验科初筛RHD阴性个体的Rh(D)血型,用血型分型卡确定Rh系统表型。结果 3795例初筛阴性标本中ccee 2139例(56.36%)、Ccee 1045例(27.54%)、ccEe 334例(8.80%)、CCee 157例(4.14%)、Cc Ee 106例(2.79%)、ccEE 12例(0.32%)、CCEe 2例(0.05%);其中D变异型144例,各表型D变异型例数及占各自总数的比例为ccee 6例(0.28%)、Ccee 21例(2.01%)、ccEe 92例(27.54%)、CCee 14例(8.91%)、Cc Ee 9例(8.49%)、ccEE 2例(16.67%),CCEe 0例。结论北京市RhD阴性献血者以ccee为主,含有E抗原的初筛Rh阴性个体为D变异型的可能性高于其他表型的个体。Objective To study the phenotype of Rh-negative individuals and to analyze the relationship between phenotype and RhD variants. Methods Routine serologic tests were used for Rhphenotype. RhD variants were detected by indirect anti-globulin test（ IAT）. Results The phenotype of the 3 795 samples were ccee 2139 cases（56. 36%）,Ccee 1045cases（27. 54%）,ccEe 334cases（ 8. 80%）,CCee 157 cases（ 4. 14%）,Cc Ee 106 cases（ 2. 79%）,ccEE 12 cases（0. 32%）,and CCEe 2 cases（0. 05%）. Among them,145 cases was RhD variants,out of whom,6 cases were ccee,21 Ccee,92 ccEe,14 CCee,9 Cc Ee,2 ccEE,and 0 case of CCEe. Conclusion The predominant phenotypes of Rh-negative individuals were ccee and Ccee in Beijing. The possibility of having E antigen in RhD negative individuals is higher than other phenotypes.

关 键 词：RHD阴性 D变异型 表型 

分 类 号：R457.11[医药卫生—治疗学] R446.61[医药卫生—临床医学]