Lewis血型系统抗体在备血患者中检出情况分析  

Analysis on detection of Lewis blood group system antibodies in patients with blood preparation

作　　者：吴思梦[1] 王秋实[1] 何燕京 海亚男 WU Simeng WANG Qiushi HE Yanjing HAI Yanan.(Shengjing Hospital of China Medical University, Shenyang 110004, China.)

机构地区：[1]中国医科大学附属盛京医院输血科,辽宁沈阳110004

出　　处：《中国输血杂志》2017年第1期70-72,共3页Chinese Journal of Blood Transfusion

摘　　要：目的调查Lewis血型系统抗体在备血患者中的检出率及分布情况。方法对抗体筛选阳性的标本做抗体鉴定。抗体筛选及交叉配血采用微柱凝胶抗球蛋白法及盐水介质试管法;抗体鉴定采用微柱凝胶抗球蛋白法;抗原鉴定采用试管法;并回顾分析本院Lewis血型系统抗体阳性患者的临床资料。结果 94例存在Lewis血型系统抗体患者中,抗-Lea89例,抗-Leb4例,抗-Le^a+Le^b1例,检出率分别是5.69×10^(-4)、0.26×10^(-4)、0.06×10^(-4);Lewis血型均为Le(a-b-);女性患者显著多于男性患者(P<0.01);妊娠期患者多见,共35例,占37.2%。17例输血患者,无1例发生溶血反应。结论 Lewis血型系统抗体意义值得探讨,盐水介质试管法和微柱凝胶抗球蛋白2种方法同时配血,可加强输血安全。Objective To investigate the detection rate and distribution of Lewis antibodies in patients with blood preparation. Methods Antibody identification was applied for screening positive specimens. Micro column gel antiglobulin method and saline medium test tube method were adopted for antibody screening and cross matching. Micro column gel antiglobulin method was also applied for antibody identification. A retrospective analysis was conducted on the clinical data from patients who had Lewis antibodies. Result Lewis antibodies were detected in 94 cases. Anti-Leawas detected in 89 cases,anti-Leb was detected in 4 cases,anti-Le^a＋ anti-Le^b co-existed in 1 case,and the detection rate were 5. 69 × 10^-4,0. 26 × 10^-4,and 0. 06 × 10^-4,respectively. Female patients were significantly more than male patients（P〈0. 01）. They were more common in pregnant patients,in a total of 35 cases,which accounted for 37. 2%. Among 17 cases of transfusion patients,no one experienced any hemolytic reaction. Conclusion The significance of Lewis blood group system antibodies is worth exploring. The adoption of micro column gel antiglobulin method and saline medium test tube method for cross matching can strengthen blood transfusion safety.

关 键 词：Lewis血型系统抗体 抗-LE^A 抗-Le^b 抗-Le^a+Le^b 

分 类 号：R457.11[医药卫生—治疗学]