儿童肥胖症与肠道菌群相关性的研究进展  

Research advances in association between childhood obesity and gut microbiota

作　　者：高晓琳[1,2] 万朝敏[1,2] 

机构地区：[1]四川大学华西第二医院儿科,四川成都610041 [2]出生缺陷与相关妇儿疾病教育部重点实验室,四川成都610041

出　　处：《中国当代儿科杂志》2017年第3期368-370,F0003,共4页Chinese Journal of Contemporary Pediatrics

基　　金：四川省科技厅支撑项目(2016SZ0019);四川省卫生和计划生育委员会科研课题(16PJ241);成都市科技局惠民项目(2014-HM01-00017-SF);四川大学华西第二医院临床科研项目基金(2016-KL010);益普生腹泻研究基金(IDF-2015-03)

摘　　要：近年越来越多的研究发现肠道菌群与肥胖症的发生发展密切相关。肠道菌群可能通过增加能量摄取、影响肠道激素分泌、引起慢性系统炎症、产生胰岛素抵抗等对儿童肥胖症产生作用。该文对儿童肥胖症与肠道菌群相关性和可能的机制进行综述,以期为儿童肥胖症的病因和防治提供参考依据。In recent years, more and more studies have noted the close association between gut microbiota and the development and progression of obesity. Gut microbiota may act on obesity by increasing energy intake, affecting the secretion of intestinal hormones, inducing chronic systemic inflammation, and producing insulin resistance. This article reviews the association between childhood obesity and gut microbiota, as well as possible mechanisms, in an attempt to provide a reference for the etiology, prevention and treatment of childhood obesity.

关 键 词：肥胖症 肠道菌群 儿童 

分 类 号：R723.14[医药卫生—儿科]