冲击波在骨科-再生医学中的应用研究进展  

Progress of shock wave therapy in orthopedics-regenerative medicine

作　　者：杨以萌 张浩[1] 廖伟雄[1] 苏祥正 张宁 李冀[1] 王克涛[1] 张恭谦 朱恒[4] 李众利[1] 

机构地区：[1]解放军总医院骨科运动医学中心,北京100853 [2]火箭军总医院,北京100088 [3]青岛世纪杰创医疗科技有限公司,山东青岛266000 [4]军事医学科学院基础医学研究所细胞生物学研究室,北京100850

出　　处：《解放军医学院学报》2017年第2期163-166,170,共5页Academic Journal of Chinese PLA Medical School

基　　金：国家科技部"十二五"科技支撑计划项目(2012BAI18B04)~~

摘　　要：冲击波作为一种花费少,疗效显著的无创治疗手段,具有镇痛和促进组织修复的作用。冲击波在骨科的应用日趋广泛,尤其是近年来有学者使用冲击波联合干细胞移植治疗股骨头坏死等疾病,发现其具有促进骨髓间充质干细胞增殖和成骨分化作用,延缓疾病的发展,为骨科-再生领域打开一扇大门。本文主要阐述冲击波的机械信号转导引起的包括骨髓间充质干细胞在内的细胞生物功能变化,介绍冲击波的应用进展和临床应用前景。Shock wave therapy（SWT） is a economic and effective noninvasive treatment that involves delivery of shock waves to the painful region with the objective of reducing pain and promoting tissue healing.SWT is widely used in orthopedics, and the combination of extracorporeal shock wave therapy and autologous bone marrow stem cells（MSCs） transplantation has been applied in treatment of osteonecrosis of femoral head.It can promote the osteoblastic differentiation and MSCs proliferation, and slow down the disease development.Therefore, SWT can be regarded as a novel treatment modality in regenerative orthopedics.This paper mainly elaborates the role of mechanical signal transduction of shock wave in cell biological functions, and its clinical application prospects of SWT.

关 键 词：冲击波 骨科 再生医学 机械信号 

分 类 号：R454.4[医药卫生—治疗学] R68[医药卫生—临床医学]