纳米喷雾干燥技术的特点及其在药物制剂领域中的应用  

The characteristics of the nano spray drying technology and its application in the pharmaceutics fields

作　　者：陈娟[1,2] 杨志强[2] 张坤[2] 潘凤[2] 王杏林[2] 

机构地区：[1]天津医科大学,天津300070 [2]天津药物研究院有限公司,释药技术与药动学国家重点实验室,天津300193

出　　处：《中国新药杂志》2017年第5期519-524,共6页Chinese Journal of New Drugs

基　　金：国家“重大新药创制”科技重大专项资助项目(2014ZX09507005-001)

摘　　要：纳米喷雾干燥技术是迅速的一步直接制备纳米级干燥粒子的新一代喷雾干燥技术,创新性的采用压电驱动喷雾头及高压静电收集器,相比于其他干燥技术,可以极小的进样量(毫克级)制备粒径范围在300 nm^5μm的高产率、粒径均匀的粒子。而且过程温和,适合热敏性材料。本文总结了纳米喷雾干燥的过程及基本原理、技术特点及其在药物制剂领域的应用。Nano spray drying technology is a new generation of drying technology for the direct drying of nanoparticles in one step,which innovativelyadopt vibrating mesh spray and high-efficiency electrostatic powder collector. Compared with other drying techniques,the device is suitable for the production of fine particles（ 300 nm-5 μm） with satisfactory yield,even for the small samples amounts（ milligrams）. The heating process is gentle,which is help to maintain the stability of the heat-sensitive material. In this paper,the basic principle and technical characteristics of nano spray drying,and also its application in the pharmaceutics fields were summarized.

关 键 词：纳米喷雾干燥 载药纳米粒 技术优势 生物利用度 应用 

分 类 号：R944[医药卫生—药剂学]