作炮制辅料用的不同姜汁对胃肠作用的差异比较  

Comparison on Effects of Different Ginger Juice on Gastrointestinal Function

作　　者：钟凌云[1] 吕沐 何平平[1] 

机构地区：[1]江西中医药大学,南昌330004

出　　处：《中国实验方剂学杂志》2017年第6期19-22,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(81460605);江西省主要学科学术和技术带头人培养计划项目(20133BCB22006)

摘　　要：目的:明确炮制辅料的生姜榨汁、生姜煮汁和干姜煮汁在胃肠作用方面的不同,探讨不同姜汁存在的差异。方法:设空白组、干姜煮汁组、生姜煮汁组和生姜榨汁组,以动物小肠推进率和抗腹泻指数为指标,给药剂量均为0.2 m L/只,考察不同姜汁对小鼠胃肠动力作用的影响;设置空白组、模型组及3个姜汁组,空白组和模型组灌胃相同体积的生理盐水,给药组分别按10 m L·kg^(-1)灌胃给药,给药30 min后除空白组外,其他各组分别按剂量5 mg·kg^(-1)腹腔注射顺铂,以动物高岭土异嗜行为考察不同姜汁的止呕作用。结果:生姜榨汁、生姜煮汁和干姜煮汁均有促进胃肠动力作用,其中以生姜煮汁作用最强,但3种姜汁均无抗腹泻作用。与模型组相比,生姜榨汁组、生姜煮汁组和干姜煮汁组异嗜高岭土量均有所减少,其中生姜煮汁组具有显著性差异。结论:3种姜汁中,生姜煮汁具有最佳的胃肠推动和止呕作用。通过明确3种姜汁在胃肠作用的差异,为后续选用适宜的姜汁炮制药物以发挥更好的药效提供依据。Objective： To investigate the difference of squeezing juice from Zingiberis Rhizoma Recens（ SJZRR）, boiling juice from Zingiberis Rhizoma Recens（ BJZRR） and Zingiberis Rhizoma（ BJZR） in gastrointestinal function. Method： The intestinal propulsion ratio and anti-diarrhea index were applied to observe the effect of different ginger juice on gastrointestinal motility,and the heterogeneous behavior after yielding of kaolin was oberseved to determine the antiemetic effect of these ginger juice. Result： SJZRR,BJZRR and BJZR all had the effects on promoting intestinal propulsion,and BJZRR had the strongest role; but they all had no anti-diarrhea effect. Compared with the model group, the amounts of kaolin in SJZRR, BJZRR and BJZR groups were all decreased,and the BJZRR group showed significant differnce. Conclusion： BJZRR shows the best effects on gastrointestinal function by comparing with SJZRR and BJZR. The results indicate that suitable ginger juice should be chosen for processing Chinese materia medica in order to get a better clinical curative effect.

关 键 词：生姜 榨汁 煮汁 干姜 小肠推进率 腹泻指数 高岭土 

分 类 号：R283.2[医药卫生—中药学] R943.1[医药卫生—中医学]