天然黄酮类化合物抗肿瘤作用靶点研究进展  

Research Progress of Anti-tumor Molecular Target in Natural Flavonoids

作　　者：孙晓润[1] 陈苹苹[1] 林悦[1] 张建平[1] 王翀奎[1] 张璇[1] 

机构地区：[1]河北中医学院基础医学院,石家庄050200

出　　处：《中国实验方剂学杂志》2017年第6期218-228,共11页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(31401003);河北省医学科学研究重点课题项目(20160214);河北中医学院青年科研基金项目(QNZ2016013)

摘　　要：天然黄酮类化合物是很多常用抗癌方剂中药物的重要有效成分。随着中草药抗癌作用研究的深入,以及抗肿瘤药物研发目标从细胞毒药物逐渐转向针对肿瘤细胞特异性信号靶点药物,天然黄酮类化合物因其低毒高效的抗肿瘤活性成为研究热点。文章综述了近年来发现的天然黄酮类化合物在肿瘤细胞生长增殖,血管生成与侵袭转移,细胞凋亡,DNA与染色体调节和多药耐药性产生等过程的主要作用靶点,这将有助于从天然黄酮类单体中寻找抗癌先导化合物,为多靶点新型抗肿瘤药物的筛选、结构改造及多聚药理学研究提供参考依据。另外,借鉴当代分子生物学的最新成果和技术手段,揭示中草药抗肿瘤作用的分子机制和组方依据也是推动中医药现代化的创新思路。文章最后对天然黄酮类化合物抗肿瘤研究的未来方向提出一些可行性建议。Flavonoids are important ingredients in many anti-tumor prescriptions in traditional Chinese medicine（ TCM）. With the deeper investigation of Chinese herbs＇ anti-tumor function, and anti-tumor drug development turning from cytotoxic regents towards cell specific signaling targets,flavonoids have gained more and more attentions in drug developing fields because of their high anti-tumor activity and low-toxicity characteristics.This paper reviewed the molecular targets of natural flavonoids that were studied in recent years in the fields of cell proliferation,agiogenesis,invasion and metastasis,apoptosis,DNA and chromosome regulations,as well as multidrug resistance production. This will help in searching anti-tumor lead compounds among natural flavonoids,and provide reference for screening and structural modification of multi-targeting anti-tumor drugs as well as the polypharmacology research. In addition,the latest achievements and technologies in modern molecular biology were used to reveal the molecular mechanism of TCM anti-tumor and prescription basis,providing a revolution way for TCM modernization. Some suggestions of anti-tumor research on natural flavonoids in the future were also given in the present review.

关 键 词：黄酮类化合物 抗肿瘤 靶点 研究进展 

分 类 号：R285.5[医药卫生—中药学]