水菖蒲倍半萜类成分的研究(Ⅱ)  

A new sesquiterpene from Acorus calamus (Ⅱ)

作　　者：李娟[1] 李兆星[2] 赵小芳[1] 徐博[1] 李林[3] 张兰[3] 李顺祥[1] LI Juan LI Zhao-xing ZHAO Xiao-fang XU Bo LI Lin ZHANG Lan LI Shun-xiang(Hunan Province Engineering Research Center of Bioactive Substance Discovery of Traditional Chinese Medicime , Hunan University of Chinese Medicine, Changsha 410208, China College of Pharmacy, Southwest Liniversity, Chongqing 400716, China Key Laboratory of Neurodegenerative Diseases of Ministry of Education, Capital Medical University, Be~jing 100053, China)

机构地区：[1]湖南中医药大学湖南省中药活性物质筛选工程技术研究中心,湖南长沙410208 [2]西南大学药学院,重庆400716 [3]首都医科大学神经变性病教育部重点实验室,北京100053

出　　处：《中国中药杂志》2017年第4期708-711,共4页China Journal of Chinese Materia Medica

基　　金：湖南省教育厅项目(15C0114);神经变性病教育部重点实验室(首都医科大学)2016年开放研究课题;湖南"中药学"重点学科项目(湘教通[2011]76号)

摘　　要：研究湖南产水菖蒲的化学成分。利用硅胶柱色谱和Sephadex LH-20柱色谱技术从水菖蒲95%乙醇浸提物中分离得到1个倍半萜类成分,结合波谱和X射线单晶衍射数据,鉴定该化合物为1R,5R,7S-guaiane-4R,10R-diol-6-one,是1个新的愈创木烷型倍半萜。A new quaiane-tgpe sesquiterpene was isolated from the 95% ethanol extract of the rhizomes of Acorus calamus by silica gel and sephadex LH-20 column chromatographic methods. Structure and absolute configuration of the sesquiterpene were elucidated by spectroscopic data and X-ray crystallographic analysis,and named as 1R,5R,7S-guaiane-4R,10R-diol-6-one.

关 键 词：水菖蒲 1R 5R 7S-guaiane-4R 10R-diol-6-one 倍半萜 愈创木烷型 

分 类 号：R284[医药卫生—中药学]