纳米级有序介孔氧化硅空心球的制备及药物缓释效果  

Synthesis and Drug Releasing Effectiveness of Hollow Mesoporous Silica Nanospheres with Ordered Mesochannels

作　　者：李世纪[1] 马宁[2] 张月[3] 刘文婷[1] 张笑妍[2] 陈智刚[1] 付建平[1] 黄勇[2] 杨金龙[2] 

机构地区：[1]中北大学机电工程学院,太原030051 [2]清华大学材料学院,新型陶瓷与精细工艺国家重点实验室,北京100084 [3]大连交通大学材料科学与工程学院,辽宁大连116021

出　　处：《硅酸盐学报》2017年第3期327-332,共6页Journal of The Chinese Ceramic Society

基　　金：国家自然科学基金(51572140);中国博士后科学基金(2015M581089)资助

摘　　要：提出一种条件温和、工艺简单的"常温水溶法"制备纳米级有序介孔氧化硅空心球,研究了该空心球作为药物伊利替康(CPT–11)的载体的载药和缓释性能。结果表明:"常温水溶法"能够制备出球形形貌规整、粒径均匀(460 nm)、高比表面积(1 237 m^2/g)且具有有序介孔孔道结构(2.7 nm)的介孔氧化硅空心球,该空心球在药物传输领域具有良好的性能,CPT–11的载药率为14.50%,在pH为7.2、5.5和4.2的环境中108 h药物的释药率分别达28.49%、39.22%和77.72%,该方法适合产业化应用,制备出的纳米级介孔氧化硅空心球有望作为CPT–11药物载体在抗肿瘤领域中得到应用。The mesoporous silica solid spheres with different silica condensation degrees inside and outside were prepared via the hydrolysis and condensation of tetraethoxysilane （TEOS）. The inner part of solid spheres is more easily dissolved rather than the outer part, and the inner part of the solid spheres is dissolved in deionized water at room temperature to obtain the hollow mesoporous silica nanospheres （HMSS） with ordered mesochannels. A facile method for preparing HMSS by water dissoving at room temperature was developed. The performance of HMSS in drug loading and releasing was investigated. The results show that this method can synthesize the HMSS with a well-defined spherical morphology, uniform particle size （i.e., 460 nm）, high specific surface area （i.e., 1 237 m2/g） and ordered mesochannels （i.e., 2.7 nm）, and the superior performance in drug releasing. The loading content of CPT-11 is 14.50%, and the drug releasing amount in 108 h at pH 7.2, 5.5 and 4.2 can reach 28.49%, 39.22% and 77.72%, respectively.

关 键 词：介孔 氧化硅 纳米空心球 药物缓释 

分 类 号：TB32[一般工业技术—材料科学与工程]