盐酸地尔硫软膏基质处方筛选  

Optimization formula of diltiazem hydrochloride ointment matrix

作　　者：彭偲偲[1] 陈冠容[1] 张亚迎 宋红萍[1] 

机构地区：[1]武汉市普爱医院药学部,湖北武汉430033

出　　处：《中国医院药学杂志》2017年第5期474-477,共4页Chinese Journal of Hospital Pharmacy

摘　　要：目的:优选盐酸地尔硫软膏的基质及处方组成。方法:采用析因分析法筛选出最优的基质处方,以外观性状、离心稳定性、耐寒耐热稳定性以及膏体延展性为考察指标对盐酸地尔硫的基质处方进行筛选,最后对优选出的处方进行质量控制。结果:最优化的处方为2%盐酸地尔硫,PEG400/4000比例为1.5:1,10%甘油,10%丙二醇,7%乙醇及2%月桂氮酮。结论:盐酸地尔硫乳膏制备方法简单,稠度与延展性适宜,性状稳定,质量可控。OBJECTIVE To optimize formulation vehicles and prescriptions of diltiazem hydrochloride ointment.METHODS The best basic formulation was chosen with factorial analysis expriments.The best prescriptions were selected by appearance observation,centrifugal stability test,heat resistance test,freeze resistance test and ductility test of the basic formulation.The quality of ointment was controlled.RESULTS Optimized prescription includes 1.5∶1 PEG400：PEG4000,2%diltiazem hydrochloride,10% glycerin,10% propylene glycol,7% ethyl alcohol and 2% azone.CONCLUSION The preparation method of diltiazem hydrochloride the ointment is simple.Denseness and ductility of the ointment are in a suitable range.The stability is good and the quality is controllable.

关 键 词：盐酸地尔硫 肛裂 软膏 聚乙二醇 

分 类 号：R944[医药卫生—药剂学]