盐酸黄连素的汇聚式合成研究  

A Concisely Convergent Synthesis of Berberine Chloride

作　　者：陈程[1] 徐蒙蒙[1] 赵青[2] 刘承秀[3] 杨鸿均[1] 冯豫川[1] Chen Cheng Xu Mengmeng Zhao Qing Liu Chengxiu Yang Hongjun Feng Yuchuan(College of Chemistry ＆ Environment Protection Engineering, Southwest University for Nationalities, Chengdu 610041 Preparatory School, Southwest University for Nationalities, Chengdu 610041 Southwest University for Nationalities Hospital, Chengdu 610041)

机构地区：[1]西南民族大学化学与环境保护工程学院,成都610041 [2]西南民族大学预科教育学院,成都610041 [3]西南民族大学校医院,成都610041

出　　处：《有机化学》2017年第2期503-507,共5页Chinese Journal of Organic Chemistry

基　　金：西南民族大学研究生创新(No.CX2015SZ045);四川省教育厅(No.15ZB0487)资助项目~~

摘　　要：报道了以1,2-亚甲二氧基苯为起始原料合成盐酸黄连素的汇聚式路线,该路线包括格氏试剂亲核开环、脱保护、环合等5步反应,总收率为33%.该路线反应条件温和、操作简单,且所有中间体及产物都经过~1H NMR、^(13)C NMR、MS鉴定.The berberine chloride was synthesized starting from benzo[d][1,3]dioxole with the mild condition and the simple operation in overall 33% yield. The route includes the five steps of nucleophilic ring opening, deprotection and cyclization and so on. All intermediates were determined by 1H NMR, 13C NMR and MS techniques.

关 键 词：盐酸黄连素 汇聚式合成 1 2-亚甲二氧基苯 格氏试剂 

分 类 号：TQ464.4[化学工程—制药化工]