碳水化合物敏感系数和胰岛素敏感系数在大剂量向导治疗中影响因素的研究  

The influencing factor analysis of the insulin-to-carbohydrate ratio and insulin sensitivity factor in bolus wizard trentment

作　　者：洛佩[1] 陈丽华[2] 陈隶华 贺艳菊[1] 李秀才[1] 徐冬香[1] 周里钢[1] 

机构地区：[1]复旦大学附属浦东医院内分泌科,上海201399 [2]复旦大学附属浦东医院科创中心,上海201399 [3]复旦大学附属浦东医院营养科,上海201399

出　　处：《蚌埠医学院学报》2016年第12期1556-1559,共4页Journal of Bengbu Medical College

基　　金：国家自然科学基金面上项目(81370932);上海市教委东方学者基金;上海市科委浦江学者基金(PJ[2011]0000839);美国MERCK IISP基金(#40313 and#40309);浦东新区领先人才项目(PWR12014-06);上海市中西医结合人才培养项目(ZYSNXD12-RC-ZXY006)

摘　　要：目的:初步探讨使用胰岛素泵大剂量向导计算器对治疗糖尿病的准确性的影响因素。方法:纳入100例2型糖尿病患者,使用胰岛素泵(CSII)治疗8 d,监测每天8次指血糖,据第1天平均血糖将患者分为3组,观察3组碳水化合物敏感系数(ICR)和胰岛素敏感系数(ISF)并作分析。结果:3组患者治疗第8天ICR和ISF差异均有统计学意义(P<0.01);治疗8 d,ICR和ISF均显著升高(P<0.01);ICR和ISF与早餐后血糖、晚餐后血糖、午餐后血糖均呈线性负相关关系(P<0.01)。结论:使用大剂量向导调整血糖过程中,ICR和ISF与患者第1天平均血糖、三餐后血糖有关;如果在治疗中不断及时调整ICR和ISF,可提高向导胰岛素剂量的准确性。Objective： To investigate the factor influencing the accuracy of diabetes treated with insulin bolus wizard pump calaculateor. Methods： A total of 100 type 2 diabetic patients were treated with insulin pump for 8 days,and the blood glucose level was measured for 8 times in a day. The patients were divided into 3 groups according to the mean blood glucose level of the first day. The insulin-to-carbohydrate ratio（ ICR） and insulin sensitivity factor（ ISF） between three groups were analyzed. Results： The ICR and ISF value in 3 groups significantly increased at 8th day of treatment（ P〈0. 01）,and the differences of ICR and ISF between three groups were statistically signifcant（ P〈0. 01）. The ICR and ISF were linearly negative correlation with the blood glucose level after breakfast,supper,and lunch（ P〈0. 01）. Conclusions： In the process of treating diabetes with bolus wizard,the ICR and ISF are related to the mean blood glucose level on the first day and glucose after meal. The timely adjusting the ICR and ISF can improve the accuracy of insulin use.

关 键 词：糖尿病 2型 大剂量向导计算器 碳水化合物敏感系数 胰岛素敏感系数 

分 类 号：R587.1[医药卫生—内分泌]