促肾上腺皮质激素释放因子受体1对阿尔茨海默病的影响（英文）  

Impact of corticotropin-releasing factor receptor 1 on alzheimer's disease

作　　者：颜彦[1,2] 陈远寿[1] 董红心[1,2] 

机构地区：[1]遵义医学院生理学教研室,贵州遵义563099 [2]西北大学芬伯格医学院精神病学和行为科学教研室,美国芝加哥60611

出　　处：《遵义医学院学报》2016年第6期639-649,共11页Journal of Zunyi Medical University

基　　金：国立卫生研究所(NIH)资助项目(NO:1R56AG053491-01)

摘　　要：越来越多的证据表明,应激后导致的促肾上腺皮质激素释放因子(CRF)以及促肾上腺皮质激素释放因子受体-1(CRFR1)与阿尔茨海默病(AD)的发病和病情发展有着密切的联系。CRFR1主要功能为下丘脑-垂体-肾上腺轴(HPA)应激后变化的重要调节因子,并且CRFR1广泛分布于与情绪和认知相关的大脑区域,鉴于此CRF/CRFR1信号通路的其他功能被提出,其中包括对AD神经病理调控。尤其新近发现CRFR1拮抗剂可阻断CRFR1下游信号对β淀粉样蛋白堆积和tau蛋白磷酸化的促进作用。因此,CRFR1拮抗剂对AD可能具有潜在的预防和治疗作用。本综述主要基于当前文献和我们的研究对CRF/CRFR1信号与AD之间的关系进行讨论。Growing evidence suggests that stress-induced release of corticotrophin-releasing factor（CRF）and subsequent effects through CRF receptor 1（CRFRl）,have been linked to Alzheimer＇s disease（AD） onset and progression.The main function of CRFRl is to act as a key regulator of stress-induced changes of the hypothalamic-pituitary-adrenal（HPA） axis.However,given the fact that CRFRl is widely located in brain areas that are associated with emotion and cognition,additional functions of CRF/CRFRl signaling have been proposed,including the regulation of AD neuropathology.In particular,specific downstream signaling of CRFR1 can promote amyloid β-protein accumulation and tau phosphorylation,which can be blocked by CRFR1 antagonist.Thus,CRFR1 antagonists may have therapeutic potential for the prevention and treatment of AD.So we reviewed current literature and our studies to clarify the relationship between CRF/CRFR1 signaling and AD.

关 键 词：应激 促肾上腺皮质激素释放因子 促肾上腺皮质激素释放因子受体-1 促肾上腺皮质激素释放因子受体-1拮抗剂 阿尔茨海默病 

分 类 号：Q42[生物学—神经生物学] R74[生物学—生理学]