带有手性侧基的α-苯乙胺分子印迹聚合物的分子识别性能  

The Molecular Recognition Properties of Chiral Molecularly Imprinted Polymers with Chiral Side Groups Based on α-Phenylethylamine

作　　者：吴亮[1] 何福岩 姚金水[1] 杨志洲[1] 刘钦泽[1] 

机构地区：[1]齐鲁工业大学材料科学与工程学院,山东济南250353

出　　处：《齐鲁工业大学学报》2016年第6期17-20,共4页Journal of Qilu University of Technology

基　　金：山东省自然科学基金(ZR2012EMZ003)

摘　　要：以α-苯乙胺的不同构型的手性异构体为模板分子,并以其为手性源合成的N-(1-苯乙基)丙烯酰胺为手性单体,采用分子印迹聚合技术合成了既含有手性侧基又含有手性空穴的双手性分子印迹聚合物。通过它们对α-苯乙胺拆分性能的研究表明:手性空穴对手性识别性能起着关键作用,单纯的手性侧基结构对手性识别性能几乎没有作用;但是,当手性侧基的构型与模板分子构型相同时,可以通过模板分子的诱导作用,对手性空穴的手性识别性能起到叠加增效作用。Using ehiral isomers of α-phenylethylamine with different configurations as the template molecules and chiral sources, and N-（ 1-phenylethyl ） arylamide which is synthesized from the chiral α- phenylethylamine as the chiral monomers, bis-chiral molecularly imprinted polymers containing both chiral side groups and chiralimprints were prepared by using the molecular imprinting polymerization technique. Resolution of α-phenylethylamine using the polymers indicated that the chiralimprints played a crucial role in molecular recognition, whereas, the chiral side groups alone scarcely had any effect on the molecular recognition properties. However, if the configuration of the side groups was the same as that of the template molecules, the chiral side groups would bring about an additive effect to the molecular recognition properties of the chiral holes.

关 键 词：手性侧基 分子印迹 分子识别 

分 类 号：O634.3[理学—高分子化学]