肺炎支原体肺炎患儿血清中白细胞介素水平与伴发喘息的相关性  

Correlation between serum levels of interleukins and concomitant wheezing in children with mycoplasma pneumoniae pneumonia

作　　者：冷红春[1] 

机构地区：[1]湖北省妇幼保健院急诊科,湖北武汉430070

出　　处：《实用临床医药杂志》2017年第3期102-104,122,共4页Journal of Clinical Medicine in Practice

基　　金：湖北省卫计委课题(WJ2015MB123)

摘　　要：目的研究和分析肺炎支原体肺炎(MPP)患儿血清中白细胞介素水平与伴发喘息的相关性。方法选取136例MPP患儿作为病例组,根据是否伴发喘息将其分为喘息组59例和非喘息组77例,根据病情将喘息组分为急性期组26例和缓解期组33例,选取60例健康儿童作为对照组。对各组患儿及对照组儿童的血清白细胞介素-4(IL-4)、白细胞介素-5(IL-5)、白细胞介素-13(IL-13)水平进行测定和比较。结果喘息组、非喘息组、对照组儿童血清IL-4、IL-5、IL-13水平的差异均有统计学意义(F=16.332、112.369、96.411,P<0.05);急性期组、缓解期组、对照组儿童血清IL-4、IL-5、IL-13水平的差异均有统计学意义(F=24.058、174.212、143.720,P<0.05);病例组患儿的血清IL-4水平与IL-5水平呈正相关关系(P<0.05),而IL-4水平与IL-13水平、IL-5水平与IL-13水平均无相关性(P>0.05)。结论 MPP患儿表现为IL-4、IL-5、IL-13等血清白细胞介素水平的升高。Objective To study and analyze the correlation between serum levels of inter- leukins and concomitant wheezing in children with mycoplasma pneumoniae pneumonia （MPP）. Methods A total of 136 children with MPP were seleeted as the case group. The children were divided into the wheezing group （n = 59） and the non-wheezing group （n = 77）. The children in the wheezing group were divided into the acute phase group （ n = 26） and the remission phase group （ n = 33） according to the condition of the disease. Sixty healthy children were selected as the control group. The serum interleukin -4 （ IL-4）, interleukin -5 （ IL-5 ）, interleukin -13 （ IL-13 ） levels were detected and compared among all the groups. Results There were significant differences in the serum IL-4, IL-5, IL-13 levels among the wheezing group, the non-wheezing group and the control group （F = 16. 332, 112. 369, 96. 411, P 〈0.05）. There were significant differences in the serum IL-4, IL-5, IL-13 levels among the acute phase group, the remission phase group and the control group （F =24. 058, 174. 212, 143. 720, P 〈 0.05）. In the case group, the serum IL-4 level was positively correlated with the IL-5 level （ P 〈 0.05 ） , and there were no correlations between the IL-4 level and the IL-13 level, the IL-5 level and the IL-13 level （P 〉 0.05）. Conclusion The serum expression of IL-4, IL-5 and IL-13 increase in patients with MPP.

关 键 词：肺炎支原体肺炎 白细胞介素 喘息 相关性分析 

分 类 号：R563.1[医药卫生—呼吸系统]