秋梨膏对纳米二氧化硅染毒大鼠血液生化指标影响的试验  

Effect of Autumn Pear Grease on Blood Biochemical Indexes of Nano Dioxide Silicon Exposed Rats

作　　者：陆敏[1] 孙湖泊 黄沛力[3] 王长文[1] 李妍[4] 

机构地区：[1]吉林医药学院公共卫生学院,吉林吉林132013 [2]北京体育大学附属医院,北京海淀100084 [3]首都医科大学公共卫生学院,北京朝阳100069 [4]吉林医药学院基础医学院,吉林吉林132013

出　　处：《中国兽医杂志》2017年第1期90-93,共4页Chinese Journal of Veterinary Medicine

摘　　要：本试验旨在研究秋梨膏对纳米二氧化硅染毒大鼠血液生化指标的影响。气管滴注法模拟人群空气吸入纳米二氧化硅构建大鼠染毒模型,进行血常规及血液生化指标检测。结果显示,秋梨膏对纳米二氧化硅染毒大鼠血液的白细胞及血小板升高具有明显的抑制作用(P<0.05),并可明显降低纳米二氧化硅引起的血液谷丙转氨酶、谷草转氨酶、尿素氮、肌酐和白蛋白增高(P<0.05),而各组氧化损伤指标和羟脯氨酸含量变化没有统计学意义(P>0.05)。结果表明,秋梨膏可以减轻纳米二氧化硅染毒大鼠血液的生化毒性。To study effect of autumn pear grease on blood biochemicalindexes of nano dioxide silicon expesedrats, tracheal instillation nano silica infected rats model was constructed in modeling crowd air suction. We detected the toxic effects of blood index. Autumn pear grease obviously inhibited the white blood cells and platelets in the blood of rats exposed to nano silica（P 〈0.05）, and it also reduced the level of blood alanine aminotransferase, aspartate aminotransferase, urea nitrogen, creatinine and albumin promoted by the nano Silica（P 〈0.05）. There had no statistically change about the oxidative damage index and the content of hydroxyproline （P〉0. 05）. Autumn pear grease can reduce the hematotoxicity caused by nano silicon.

关 键 词：雾霾 超细颗粒物 秋梨膏 纳米二氧化硅 血液毒性 

分 类 号：R122.2[医药卫生—环境卫生学]