中药灌肠联合常规疗法治疗慢性肾脏病效果观察  

Observation of Chinese Medicine Enema Combined with Routine Treatment for CKD

作　　者：陈建胜 庄昌辉 罗彤 李小影 林义 池晓倩 CHEN Jiansheng ZHUANG Changhui LUO Tong LI Xiaoying LIN Yi CHI Xiaoqian

机构地区：[1]瑞安市中医院肾内科,浙江瑞安325200

出　　处：《新中医》2017年第3期50-52,共3页New Chinese Medicine

基　　金：浙江省温州市卫生局课题(2014zb010)

摘　　要：目的:观察中药灌肠联合常规疗法治疗慢性肾脏病(CKD)的临床疗效。方法:选取159例慢性肾脏病3~5期的非透析患者作为研究对象,按照随机数字表法将其分成3组,每组53例。A组给予常规治疗,B组给予中药灌肠治疗,C组给予常规治疗联合中药灌肠治疗,比较3组的治疗效果,并观察血清磷(P)、钙(Ca)、全段甲状旁腺激素(iPTH)、碱性磷酸酶(ALP)水平以及腰椎骨密度(BMD)的变化。结果:C组总有效率为86.79%,均高于A组、B组,差异均有统计学意义(P<0.01,P<0.05);A组总有效率与B组比较,差异无统计学意义(P>0.05)。治疗后,3组血清Ca水平均较治疗前上升(P<0.01),血清P、iPTH、ALP均较治疗前下降(P<0.01);C组血清Ca水平高于A组、B组(P<0.01),血清P、iPTH、ALP水平低于A组、B组(P<0.01);B组各项指标改善情况均优于A组(P<0.01)。3组腰椎BMD值均较治疗前增加(P<0.01),C组腰椎BMD值高于A组、B组(P<0.01,P<0.05),B组腰椎BMD值高于A组(P<0.01)。结论:在常规治疗基础上联合中药灌肠治疗CKD疗效显著,能有效调节钙磷代谢,利于骨代谢恢复正常。Objective：To observe the clinical curative effect of Chinese medicine enema combined with routine treatment for Chronic kidney disease（CKD）.Methods：Selected 159 CKD patients under three to five period without dialysis,divided them into three groups according to the random digital table method with 53 cases in each.Group A was given routine treatment,group B was treated with Chinese medicine enema,while group C was treated with Chinese medicine enema combined with routine treatment.Compared efficacy of the three groups,and observed variation of levels of serum P（phosphorus）,Ca（calcium）,intact parathyroid hormone（iPTH）,levels of alkaline phosphatase（ALP）,lumbar vertebrae bone mineral density（BMD）.Results：The total effective rate of group C was 86.79%,being higher than that of the group A and group B（P〈0.01,P〈0.05）.There was no significant different between group A and group B（P〈0.05）.After treatment,serum Ca levels of the three groups were all higher than those before treatment（P〈0.01）,serum P,iPTH and ALP were all lower than those before treatment（P〈0.01）.Serum Ca levels of group C was higher than those of group A and group B（P〈0.01）,serum P,iPTH and ALP of group C were all lower than those of group A and group B（P〈0.01）.Improvement of every index in group B was better than that in group A（P〈0.01）.Scores of lumbar vertebrae BMD in three groups were all higher than those before treatment（P〈0.01）.Scores of lumbar vertebrae BMD of group C were all higher than those of group A and group B（P〈0.01,P〈0.05）,those of group B were higher than those of group A（P〈0.01）.Conclusion：Chinese medicine enema that based on the routine treatment has remarkable curative effect,which can regulate Ca and P metabolism effectively,and is good for the recovery of bone metabolism.

关 键 词：慢性肾脏病(CKD) 矿物质与骨代谢异常 中西医结合疗法 中药灌肠 骨密度(BMD) 钙磷代谢 

分 类 号：R692[医药卫生—泌尿科学]