相位值定量评估原发性不宁腿综合征脑灰质核团铁含量  

Quantitative estimation of regional brain gray nuclei iron content in idiopathic restless legs syndrome patients by phase values

作　　者：唐小平[1] 于建华[1] 肖新兰[1] 漆学良[2] 尹建华[1] 

机构地区：[1]南昌大学第二附属医院MRI室,330006 [2]南昌大学第二附属医院神经内科,330006

出　　处：《中华放射学杂志》2017年第3期161-165,共5页Chinese Journal of Radiology

基　　金：江西省卫生计生委科技计划项目（20155281）

摘　　要：目的 探讨增强梯度回波T2^＊加权血管成像序列（ESWAN）相位值定量评价原发性不宁腿综合征（RLS）患者脑内灰质核团铁含量的应用价值,为原发性RLS的诊治提供影像依据.方法 2012年6月至2016年4月45例原发性RLS患者（RLS组）和45名健康志愿者（对照组）行颅脑ESWAN技术扫描及血清铁蛋白检测,对ESWAN原始图像后处理获得相位图.ROI置于相位图脑内灰质核团（黑质、红核、齿状核、丘脑、苍白球、壳核、尾状核）进行相位分析.采用以年龄为协变量的协方差分析（ANCOVA）比较两组ROI对应的相位值及血清铁蛋白浓度有无差异.结果 RLS组黑质、丘脑、苍白球及壳核部位的相位值分别为（-0.087±0.021）、（-0.053±0.012）、（-0.161±0.008）、（-0.125±0.019）弧度,对照组分别为（-0.127±0.007）、（-0.066±0.007）、（-0.166±0.007）、（-0.150±0.010）弧度,两组间差异有统计学意义（F值分别为142.492、37.988、10.558、60.725,P值均〈0.05）,提示RLS患者脑内部分灰质核团铁含量低.RLS组血清铁蛋白（157.02±95.78）μg/L与对照组（175.49±38.65）μg/L比较差异无统计学意义（F=1.353,P〉0.05）.结论 相位值能活体定量评估原发性RLS脑内低铁含量,支持脑内铁减少在原发性RLS发病机制中起重要作用,但脑铁代谢变化与血清铁蛋白浓度变化并不完全一致.Objective To investigate the applicative value of enhanced 3D multi-echo GRE T2^＊-weighted angiography（ESWAN） sequence phase values in evaluating brain gray nuclei iron content in idiopathic restless legs syndrome（RLS） patients, providing imaging basis in diagnosis and treatment of idiopathic RLS. Methods In our institute from June 2012 to September 2016,forty-five RLS patients were selected as the RLS group, and 45 healthy volunteers as the control group. ESWAN sequence was performed and serum ferritin values were obtained in all patients and volunteers. The raw data of ESWAN was postprocessed , where the phase maps were obtained. Phase analysis was performed on localized brain gray nuclei regions of interest （substantia nigra, red nucleus, dentate nucleus, thalamus, pallidum, putamen and caudate nucleus ） selected on phase maps. Differences between the 2 subject groups were evaluated using ANCOVA including age as a covariate. Results The phase values of the substantia nigra, thalamus, pallidum and putamen in the RLS group were （-0.087 ± 0.021）, （-0.053 ± 0.012）, （-0.161 ± 0.008）, （-0.125 ± 0.019） radians , respectively. The phase values of the substantia nigra, thalamus, pallidum and putamen in the control group were （-0.127 ± 0.007）, （-0.066 ± 0.007）, （-0.166 ± 0.007）, （-0.150 ± 0.010） radians, respectively. There were significant differences between the two groups （F=142.492, 37.988, 10.558, 60.725;P〈0.05）. Indicating reduced iron content in several regions of brain gray nuclei of the patients with RLS. Serum ferritin concentration between the RLS patients （157.02±95.78）μg/L and healthy controls （175.49 ± 38.65）μg/L was not significant （F=1.353,P〉0.05）. Conclusions Phase values can make a quantitative assessment of brain gray nuclei iron content in RLS patients, our results supported the hypothesis of reduced brain iron content in RLS patents , which may have an important role in the pathogenesis of the disorder. However, iron conte

关 键 词：不宁腿综合征 铁 磁共振成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R741[医药卫生—诊断学]