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机构地区:[1]郑州大学附属南阳市中心医院肾病风湿免疫科,河南南阳473400 [2]郑州大学附属南阳市中心医院骨二科,河南南阳473400 [3]郑州大学附属南阳市中心医院泌尿外科,河南南阳473400
出 处:《中国比较医学杂志》2017年第1期73-78,共6页Chinese Journal of Comparative Medicine
摘 要:目的探究不同剂量的淫羊藿苷对实验性Ig A肾病大鼠的影响,并研究其相关作用机制。方法建立实验性Ig A肾病大鼠模型,实验共分为5组,正常对照组(con),造模组(Ig A),淫羊藿苷低剂量组(ICA-L),淫羊藿苷中剂量组(ICA-M)和淫羊藿苷高剂量组(ICA-H);各组经相应处理后,测定各组大鼠尿红细胞、尿蛋白和尿NAG水平;免疫荧光染色检测Ig A沉淀情况;免疫组化染色法与实时荧光定量PCR分别检测NF-κBp65与MCP-1的蛋白表达水平和IL-4,IL-10与IL-13的mRNA表达变化。结果给予淫羊藿苷处理后,降低实验性Ig A肾病大鼠的尿红细胞、尿蛋白和尿NAG水平与减少Ig A沉淀,并降低NF-κBp65与MCP-1的蛋白表达水平和IL-4,IL-10与IL-13的mRNA表达。结论淫羊藿苷对实验性Ig A肾病有一定的疗效,可能与调控NF-κBp65,MCP-1因子的表达以及机体免疫调节有关。Objective To investigate the effect of Icariin (1CA) experimental IgA nephropathy in rats and to explore related mechanisms. Methods Experimental IgA nephropathy rat model was established and then model rat were treated with or without different doses of ICA. Then, urine RBC, Urine protein and urine NAG were analyzed; IgA precipitation was detected with immunofluoreseence staining; the protein level of NF-KBp65 and MCP-1 were examined by immunohistoehemical staining; the mRNA level of IL-4, IL-10 and IL-13 were determined by quantitative PCR. Results The concentrations of urine RBC, Urine protein and urine NAG were reduced after ICA treatment, as companied by a decrease of IgA precipitation. Moreover, ICA treatment also decreased the protein level of NF-KBp65 and MCP-1, and the mRNA level of IL-4, IL-10 and IL-13. Conclusions ICA exerts a certain degree of efficacy on the treatment of experimental lgA nephropathy through regulating NF-KBp65 and MCP-1 expression and the immunoregulation mechanism.
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