两亲分子有序组合体与生物活性分子的相互作用  

Interaction between organized assemblies of amphiphilic molecules and biological active molecules

作　　者：刘燕[1] 郭荣[1] 

机构地区：[1]扬州大学化学化工学院,扬州225002

出　　处：《科学通报》2017年第6期486-497,共12页Chinese Science Bulletin

基　　金：国家自然科学基金(21173182;21573190);江苏高校优势学科建设工程;江苏省高校自然科学研究重大项目(15KJA150009)资助

摘　　要：丰富多样的两亲分子有序组合体在生命科学中扮演着十分重要的角色.因此,研究两亲分子有序组合体与生物活性分子的相互作用具有重要的理论和实践意义.近年来,本课题组在这方面开展了系列工作,主要包括绿色表面活性剂在水溶液中的组装行为及组装机制、两亲分子有序组合体与生物活性分子的结合特性、两亲分子有序组合体对药物性能的调控以及对药物的控制释放.本文在简要介绍国内学者相关工作的基础上,综述了本课题组的相关工作并对相关研究的发展方向做了进一步展望.Organized assemblies formed by amphiphilic molecules have various structures, including micelles, microemulsions, vesicles, lamellar liquid crystals, and hydrogel. Due to the similarity between the basic structure of the life system and molecular organized assemblies, these organized assemblies are of much importance as a convenient model for studying the biomacromolecules such as protein and phospholipids bilayer and also of great significance from the viewpoint of various promising practical applications. Therefore, it is of great theoretical and practical significance to study the interaction between organized assemblies of amphiphilic molecules and biological active molecules. In recent years, we have carried out a series of work in this area. We designed and synthesized some amino acid, glucoside and ionic liquid based functional green surfactants. These new surfactants can self-assemble into organized assemblies having various structures, such as micelles, vesicles, lamellar liquid crystals, and hydrogel. The mutual transformation among these different molecular ordered assemblies can be regulated by the molecular structure of surfactants and environmental factors. The molecular self-assembly of surfactants based on noncovalent interactions, such as hydrogen-bond, static electricity, solvophobic interaction and n-n stacking, etc, provides a powerful tool for the creation of well-defined structures in certain dimensions, and the transform among these organized assemblies. Furthermore, the interaction relationship between amphiphilic molecules and biological active molecules has been revealed by studying their thermodynamic and kinetic characteristics. Methemoglobin and GDA/n-C5H11OH/H2O assemblies can affect their structures and properties, and the change in behavior is dependent on the content of methemoglobin and the composition and structure of the GDA/n-C5H11OH/H2O system. The existence of methemoglobin reduces the hexagonal liquid crystal region, while the lamellar liquid crystal region is little change

关 键 词：两亲分子 分子有序组合体 生物活性分子 相互作用 

分 类 号：O641.3[理学—物理化学]