夏王散结胶囊提取工艺研究  

A Study of the Extraction Technology for Xiawang Sanjie Capsule

作　　者：魏冉[1] 徐莉[2] 林桂涛[1] WEI Ran XU Li LIN Guitao(Pharmaceutical college,Shandong University of Traditional Chinese Medicine,Jinan 250355,China Qilu Hospital,Jinan 250012,China)

机构地区：[1]山东中医药大学药学院,山东济南250355 [2]齐鲁医院,山东济南250012

出　　处：《山东中医杂志》2017年第3期237-240,共4页Shandong Journal of Traditional Chinese Medicine

基　　金：国家科技重大专项重大新药创制(编号:2009ZX09301-013)

摘　　要：目的:确定夏王散结胶囊的提取工艺,保证其安全性和有效性。方法:根据处方中各药味有效成分的性质,分别采用煎煮法提取和乙醇回流法提取。以有效成分提取量、乙醇可溶物的量和正丁醇可溶物的量为指标,用正交试验法考察、优选最佳提取工艺条件。结果:夏枯草、王不留行、浙贝母、山慈菇、柴胡用70%乙醇回流提取两次,分别加10倍量和8倍量溶剂,每次提取3 h;莪术、白术、香附提取挥发油后的药渣与牡蛎、昆布加水浸泡1 h,煎煮两次,分别加8倍量和6倍量水,每次2 h。结论:确定的提取工艺较好地提取了有效成分,可保证制剂的有效性和安全性。Objective：To determine the extraction technology of the Xiawang Sanjie capsule, and to ensure its safety and effectiveness. Methods：According to the properties of the active ingredients of each Chinese herb, herbs were extracted using decoction method and ethanol reflux extraction. The optimized extraction condi- tions were determined by orthogonal test,with the extracted amount,the amount of ethanol soluble matter and the amount of the n-butanol soluble matter as the index. Resuhs：Xiakucao（Prunella）,Wang Bu Liu Xing （ Vaccaria） ,Zhe Bei Mu （ Fritillaria） ,Shah Cigu （ indica） ,and Chaihu （bupleurum ） were extracted with 70% ethanol reflux extraction for 2 time 3 hr per for each time,with 10 folds and 8 folds amount of solvent added, respectively. After extracted for volatile oil, Ezhu （ Curc uma ） , Baizhu （ A tractylodes ） ,X ianffu （ C yperus ） were mixed with mu li（Concha Ostreae）,Kunbu（Thallus Laminariae） and water for 1 hr,and then decocted for 2 times,2 hr per time,with 8 folds and 6 folds amount of water,respectively. Conclusion ：The extraction technology could extract the active ingredients effectively,which can ensure the effectiveness and safety of the preparation.

关 键 词：夏王散结胶囊 乳腺增生症 提取工艺 正交试验 

分 类 号：R283.6[医药卫生—中药学]