经方枳实薤白桂枝汤颗粒剂标准研究  

A Study on the Quality Standard of Zhishi Xiebai Guizhi Decoction Granules

作　　者：丛中笑[1] 盛华刚[1] 林桂涛[1] CONG Zhongxiao SHENG Huagang LIN Guitao(Shandong University of Traditional Chinese medicine,Jinan 250355,Chin)

机构地区：[1]山东中医药大学,山东济南250355

出　　处：《山东中医杂志》2017年第3期241-244,共4页Shandong Journal of Traditional Chinese Medicine

基　　金：国家科技重大专项"重大新药创制"(编号:2009ZX09301-013)

摘　　要：目的 :建立枳实薤白桂枝汤颗粒剂的质量标准。方法 :采用薄层色谱(TLC)法对制剂中的药味进行薄层鉴别;以柚皮苷为指标,采用高效液相色谱(HPLC)法对制剂中的枳实进行含量测定。结果:成功鉴别了枳实和厚朴;柚皮苷在15.12~151.2μg/m L(r=0.9998)范围内有良好的线性关系,平均回收率101.13%,RSD为1.53%(n=9),方法的稳定性、精密度、重复性和重现性均较好。结论:制定的标准准确、简便,可以较好地控制枳实薤白桂枝汤颗粒剂的质量。Objective：To establish the quality standard of Zhishi Xiebai Guizhi decoction granules. Methods： By using thin layer chromatography（TLC） herbs in the granules were analyzed. Naringin was as the indicator, high performance liquid chromatography（HPLC） was applied to determine the content of Zhishi（Citrus auran- tium）. Results ：Zhishi （Citrus aurantium） and Houpo （Magnolia） were successfully identified. Naringin showed a good linear relationship within 15.12--151.2 μg/mL（r=0.9998）,with the average recovery rate 101.13% and relative standard deviation（RSD） 1.53% （n=9）. This method was stable,accurate,repeatable and reproducible. Conclusion：This quality standard is accurate and simple,and it provides a scientific basis for quality control of Zhishi Xiebai Guizhi decoction granules.

关 键 词：枳实薤白桂枝汤 颗粒剂 质量标准 薄层色谱法 高效液相色谱法 

分 类 号：R283.6[医药卫生—中药学]