1%卢立康唑乳膏治疗足癣的临床疗效观察  

Evaluation of clinical efficacy of 1% luliconazole cream in the treatment of tinea pedis

作　　者：杨静[1] 董碧麟[1] 江萍[1] 尹婧[1] 陈尊义[1] 张伟明[1] 夏凡[1] 赖彬[1] 童中胜[1] 

机构地区：[1]武汉市第一医院皮肤科,武汉430022

出　　处：《中国真菌学杂志》2017年第1期45-48,共4页Chinese Journal of Mycology

基　　金：中国中西医结合学会皮肤性病专业委员会临床研究基金(CAIM-LLKZ-008)

摘　　要：目的评价1%卢立康唑乳膏治疗足癣的疗效和安全性。方法将120例患者随机分为4组,包括实验组卢立康唑2周组、卢立康唑4周组及对照组萘替芬酮康唑2周组、萘替芬酮康唑4周组。在用药结束时及停药后2周评价临床和真菌学疗效。结果卢立康唑2周组停药时,临床有效率为67.86%,对照组为70.37%(P>0.05)。真菌清除率为46.43%,对照组为51.85%(P>0.05);停药后2周,卢立康唑2周组临床有效率为85.71%,对照组为85.19%(P>0.05)。真菌清除率为82.14%,对照组为81.48%(P>0.05)。卢立康唑4周组停药时,临床有效率为88.89%,对照组为88.89%(P>0.05)。真菌清除率为85.19%,对照组为88.89%(P>0.05);停药后2周,卢立康唑4周组临床有效率为92.59%,对照组为88.89%(P>0.05)。真菌清除率为88.89%,对照组为88.89%(P>0.05);试验组和对照组药物不良反应均表现为局部刺激,发生率均为3.33%。结论 1%卢立康唑乳膏治疗足癣的疗效及安全性与萘替芬酮康唑乳膏相似。1%卢立康唑乳膏外用治疗足癣安全有效,每日1次治疗2周与治疗4周的疗效相当。Objective To evaluate the efficacy and safety of luliconazole 1% cream in the treatment of tinea pedis.Methods One hundred and twenty patients positive for fungal elements on direct microscopy were equally and randomly divided into 4groups：the trial groups applying luliconazole 1%cream for 2weeks or 4weeks and the control groups applying naftifine ketoconazole 2weeks or4 weeks.Efficacy was assessed in terms of mycological clearance and clinical response rates on week 2,4and 6after initiation of treatment.Results In 2-week regimen,the clinical response rates at weeks 2were 67.86%in trial group and 70.37%in control group（P〉0.05）;The mycological clearance rates were 46.43%in trial group and 51.85%in control group（P〉0.05）.They were 85.71%vs.85.19% and 82.14%vs.81.48%respectively at weeks 4（2weeks after the end of treatment）（P〉0.05）.In4-weekregimen,the clinical response rates were 88.89% vs.88.89%and mycological clearance rates were 85.19% vs.88.89%at weeks 4.They were 92.59%vs.88.89% and 88.89% vs.88.89%respectively on 2weeks after the end of treatment（P〉0.05）.Treatment-related adverse events consisted of local irritation occurred in 3.33%of patients both in the trial group and control group.Conclusion The efficacy and safety of 1%luliconazole cream in the treatment of tinea pedis are similar to that of naftifine ketoconazole cream.This study suggests that1%luliconazole cream was effective and safe in the treatment of tinea pedis,with the efficacy of 2-week once-daily regimen equivalent to that of 4-week once-daily regimen.

关 键 词：卢立康唑乳膏 萘替芬酮康唑乳膏 足癣 临床疗效 

分 类 号：R756.3[医药卫生—皮肤病学与性病学]