Caspase-11在固有免疫中的作用  

The role of caspase-11 in the immune inflammatory response

作　　者：洪旭东[1] 肖永强[1] 陈甜胜 罗鹏飞[1] 夏照帆[1] Hong Xudong Xiao Yongqiang Chen Tian- sheng Luo Pengfei Xia Zhaofan(Department of Burn Surgery, Changhai Hospital, the Second Military Medical University, Shanghai 200433, Chin)

机构地区：[1]第二军医大学第一附属医院长海医院烧伤外科,上海200433

出　　处：《国际免疫学杂志》2017年第1期46-50,共5页International Journal of Immunology

基　　金：基金项目：国家973计划项目（2012CB518100）;国家自然科学基金国际（地区）合作与交流项目（81120108015）;十二五科技计划（AWS11J008）

摘　　要：半胱氨酸的天冬氨酸蛋白水解酶Caspase-11与胞内宿主炎症模式识别受体（hostpatternrecognitionreceptors，PRR）、炎症小体转接器ASC三部分组成caspase-11炎性小体复合物，被脂多糖的6．乙酰基脂质A识别，进而激活机体固有免疫应答反应。细胞内吞脂多糖（1ipopolysaccharide，LPS）后，caspase-11在细胞质内特异识别定位的何种细胞器一直未有明确定论，为精准地靶向定位带来一些困难。脂多糖激活caspase-11可以导致IL-1β／IL-18相关的炎性反应及pannexin-1、GSDMD介导细胞焦亡。Caspase-11的胞内信号靶点探索，将是未来某些疾病治疗新的研究方向，如结肠癌、GSDMD相关的脱毛症等。Inflammatory caspases are homologous between each other, becoming research hotpot once found. Caspase-11 is one of the main inflammatory caspases. Caspase-11, together with inflammatory host pat- tern recognition receptors （PRR）, apoptosis-associated speck-like protein containing CARD （ASC） constitutes caspase-11 inflammasome. Most gram-negative bacterium lipid A have six acyl chains, herafter termed ＇ hexa- acylated＇ lipid A. These lipids can activate innate immune response. Lipopolysaccharide enters cell cytoplasm by endocytosis. However, the organelles in which easpase-11 is activated are not clear. This makes it difficult for targeted treatment. The activation of caspase-ll by lipopolysaccharide（LPS） leads to IL-1β/IL-18 related inflammatory reaction and pannexin-1/GSDMD mediated pyroptosis. The exploration of the signaling pathways of caspase-11, is a novel research point in the diseases, such as colon cancer and GSDMD mediated alopecia.

关 键 词：Caspase-11 脂多糖 炎症因子 细胞焦亡 

分 类 号：R392[医药卫生—免疫学]