C型趋化因子XCL1研究进展  

Progress in research on C-chemokine XCL1

作　　者：余磊[1] 杨贵波[1] Lei Yu Gui-Bo Yang(National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China)

机构地区：[1]中国疾病预防控制中心性病艾滋病预防控制中心,北京市102206

出　　处：《世界华人消化杂志》2017年第7期602-609,共8页World Chinese Journal of Digestology

基　　金：国家自然科学基金资助项目;No.81571607;北京市自然科学基金资助项目;No.7162136~~

摘　　要：C型趋化因子家族唯一成员XCL1,又称淋巴趋化因子,主要由CD8+T细胞和自然杀伤细胞产生.XCL1具有独特的序列特征以及两种可相互转换的蛋白空间构象,使得XCL1有别于其他趋化因子并发挥独特的功能.XCL1特异性受体XCR1是G蛋白偶联受体家族成员,二者相互作用不仅在胸腺的阴性选择和建立自身免疫耐受中发挥重要作用,而且能启动交叉抗原递呈并介导细胞毒性免疫反应.XCL1不仅能调节免疫系统平衡,维持肠道免疫稳态,而且与多种疾病相关,如自身免疫病、肾炎、结核和人类免疫缺陷病毒感染等.近年来证实XCR1选择性地表达在具有抗原递呈能力的CD8+DCs细胞上,引发许多XCL1相关应用研究并取得很好的效果,使得XCL1在黏膜免疫,抗肿瘤免疫治疗和靶向疫苗研制方面具有广阔的应用前景.XCLl,also known as lymphotactin,is the only known member of the C-type-chemokine family,which is produced mainly by CD8~＋T cells and natural killer cells.XCL1 has a unique amino acid sequence feature and two interchangeable conformations,which makes XCL1 different from other chemokines in structure and function.The XCL1-specific receptor,XCR1,is a member of the G-protein-coupled receptor family and plays an important role in the negative selection of T cells in the thymus and in the initiation of cross-antigen presentation and mediation of cytotoxic immune responses.XCL1 can regulate the balance of the immune system and maintain intestinal immune homeostasis,and it is involved in a variety of diseases such as autoimmune diseases,nephritis,tuberculosis and human immunodeficiency virus infection.In recent years,the selective expression of XCR1 on CD8~＋ DCs with strong cross antigenpresention ability has been proved,which has led to studies using XCL1 for mucosal immunization,antitumor immunotherapy and targeted vaccine development.

关 键 词：XCL1 CD8+DCs CTL反应 黏膜免疫佐剂 疫苗研制 

分 类 号：R392[医药卫生—免疫学]