新型速溶技术在速释制剂研究中的应用  

Applications of Noval Fast-dissolving Technologies to Development of Rapid-release Preparations

作　　者：鞠晓莉 何军[1] 杨亚妮[1] 卞玮[1] 倪美萍[1] 

机构地区：[1]中国医药工业研究总院药物制剂国家工程研究中心,上海201203

出　　处：《中国医药工业杂志》2017年第3期434-441,共8页Chinese Journal of Pharmaceuticals

摘　　要：目前,速溶药物传递系统研究的主要内容包括口腔崩解片和口腔速溶膜,它们无需水或咀嚼便能在1 min内快速崩解,因而改善了患者的依从性。近年来,许多新型速溶技术的出现,进一步推动了速溶药物传递系统的发展。本文介绍了几种新型速溶技术,如冷冻干燥技术、3D打印技术和预混崩解剂在制备口腔崩解片,以及静电纺丝技术、热熔挤出技术、喷墨打印和柔性打印在制备口腔速溶膜中的应用,并简要总结了上述新型速溶技术的优缺点。At present, orally disintegrating tablets and fast dissolving oral films are the main research directions of fast dissolving drug delivery system （FDDDS）, which can dissolve or disintegrate within a minute without drinking water or mastication so as to improve patient compliance. In recent years, many novel fast-dissolving technologies have promoted the development of FDDDS. This review introduces some applications of several noval fast-dissolving technologies to preparation of orally disintegrating tablets and fast dissolving oral films, such as freeze-dried thchnology, three-dimensional printing, co-processed disintegrants, electrospinning, hot melt extrusion, ink-jet printing and flexographic printing technology. Their advantages and disadvantages are brifely introduced as well.

关 键 词：速溶药物传递系统 新型速溶技术 口腔崩解片 口腔速溶膜 综述 

分 类 号：R944.9[医药卫生—药剂学]