正交试验优选消痔灵洗剂水提工艺  

Optimization of the Water Extraction Process of Xiaozhiling Lotion by Orthogonal Test

作　　者：王欣欣[1] 曹佩雪[2] 华玉玲[1] 苏松柏[1] WANG Xin - xin CAO Pai - xue HUA Yu - ling SU Song - bai(The First Affiliated Hospital of Guiyang University of Chinese Medicine, Guiyang 550001, Guizhou China Key Laboratory of Natural Product Chemistry, Chinese Academy of Sciences, Guiyang 550002, Guizhou China)

机构地区：[1]贵阳中医学院第一附属医院,贵州贵阳550001 [2]贵州省中国科学院天然产物化学重点实验室,贵州贵阳550002

出　　处：《贵阳中医学院学报》2017年第2期23-26,共4页Journal of Guiyang University of Chinese Medicine

基　　金：贵州省中医药管理局贵州省中医药;民族医药科学技术研究专项课题;项目编号:QZYY2013-45

摘　　要：目的:优选消痔灵洗剂的水提工艺。方法:以苦参碱和氧化苦参碱的含量为评价指标,按正交表L_9(3~4)设计试验,考察加水量、提取时间和提取次数3个因素。结果:提取时间对提取效果有显著影响,提取工艺的最佳参数为:加水量为10倍,提取时间为每次1h,提取次数为2次。结论:优选的提取工艺能较好地保证制剂的质量。Objective： To optimize the water extraction process of Xiaozhiling lotion. Methods： The extraction technology of Xiaozhiling Lotion was optimized by L9 （ 3^4 ） orthogonal test. Took the content of matrine and oxymatrine as index to evaluate three factors of the amount of the added - water, the duration of decoction and the frequency of decoction. Results： The frequency of decoction was the most important factor in the extraction process. The procedure of the best extraction technology was when adding 10 times of water, decocting twice with 1 hour each time. Conclusion： The optimal extraction technology shows the stabilization and feasibility in controling the quality of theproduetion.

关 键 词：消痔灵洗剂 正交试验 提取工艺 苦参碱 氧化苦参碱 

分 类 号：R284.2[医药卫生—中药学] R286.0[医药卫生—中医学]