痛泻要方治疗腹泻型肠易激综合征临床研究的Meta分析  

Meta-analysis of Diarrhea-predominant Irritable Bowel Syndrome Treated by Tongxie Yaofang(痛泻要方)

作　　者：赵海燕[1] 胡乃强[1] 黄适[2] 黄婷[1] 林福旭 王松[1] ZHAO Hai-yan HU Nai-qiang HUANG Shi HUANG Ting LIN Fu-xu WANG Song(Guangxi University of Chinese Medicine, Nanning Guangxi 530001, China Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning Guangxi 530011, China)

机构地区：[1]广西中医药大学,广西南宁530001 [2]广西中医药大学附属瑞康医院,广西南宁530011

出　　处：《中医药导报》2017年第4期78-81,共4页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金项目(81560754);广西自然科学基金项目(2015GXNSFAA139199)

摘　　要：目的:通过运用Meta分析评价痛泻要方治疗腹泻型肠易激综合征的临床疗效。方法:检索2016年以前有关痛泻要方治疗腹泻型肠易激综合征的临床试验性研究文献,采用Jadad质量计分法对纳入的研究进行质量评价,运用Rev Man 5.3.0软件进行Meta分析。结果:最终将纳入的符合标准的7篇文献进行异质性检验:χ2=1.96,P=0.92>0.1,I2=0%,可使用固定模式进行Meta分析,合并效应量OR值为4.17,可信区间95%CI(2.62,6.65),P<0.00001,差异有统计学意义,治疗组疗效优于对照组。倒置的"漏斗图"显示未见明显的发表偏倚。结论:痛泻要方治疗腹泻型肠易激综合征的临床疗效显著,但纳入的研究文献均为小样本文献,方法学质量评价不高,故仍需大量的多样本的、多中心的随机对照试验(RCT)进行进一步的证实。Objective： To study the clinical efficacy of diarrhea-predominant irritable bowel syndrome （IBSD） using Meta-analysis. Methods： The literature about Tongxie Yaofang （痛泻要方） treatment of diarrhea-predominant irritable bowel syndrome was collected before 2016, then use Jadad quality scoring method evaluating the quality of the included studies, and analyze the results with software RevMan5.3.0 Meta-analysis. Results： The results of heterogeneity test was χ^2=1.96, P=0.92〉0.1, P=0%, then we chosen a fixed pattern Meta-analysis, the combined effect size OR=4.17, 95% CI （2.62, 6.65）, P〈0.00001, the difference was statistically significant; it is considered that the effect of treatment group was better than the control group. ＂Funnel plot＂ shows no significant publication bias. Conclusion： The effect of Tongxie Yaofang on diarrhea-predominant irritable bowel syn- drnme was significantly, but the research literature included is the small sample literature, and the methodological quality evaluation is not high, so there still need large number of diverse, multi-center, randomized controlled trials （RCT） to give a further confirmed.

关 键 词：腹泻型肠易激综合征 痛泻要方 随机对照试验(RCT) META分析 

分 类 号：R256.3[医药卫生—中医内科学]