丹参多酚酸盐注射液联合PCI术对稳定性心绞痛患者冠状动脉微循环和血液流变学指标的影响  

The Effect of Salvianolate Injection combined PCI Surgery on Coronary Microcirculation and Hemorrheology in Patients with Stable Angina

作　　者：徐燕 刘存义 宋雷[3] XU yan LIU Cun-yi SONG Lei(Beijing Wangfu Hospital of Integrated Traditional Chinese and Western Medicine, Beijing 102209, China Beijing Red Cross Emergency Rescue Center, Beijing 100085 Beijing Fuwai Hospital of Cardiovascular Disease, Beijing 100000, China)

机构地区：[1]北京王府中西医结合医院,北京102209 [2]北京市红十字会急诊抢救中心,北京100085 [3]北京阜外心血管病医院,北京100000

出　　处：《中医药导报》2017年第4期86-88,92,共4页Guiding Journal of Traditional Chinese Medicine and Pharmacy

摘　　要：目的:探讨丹参多酚酸盐注射液联合PCI术治疗稳定性心绞痛的临床疗效。方法:将符合纳入标准的168例稳定性心绞痛患者随机分为治疗组和对照组各84例。对照组接受PCI术治疗,治疗组在对照组基础上,予丹参多酚酸盐注射液。分析比较两组心肌损伤标志物、冠状动脉微循环以及血液流变学等指标的变化。结果:治疗组总有效率为88.1%,高于对照组的52.4%(P<0.05);两组治疗后LVEF、LVEDD、IMR(前降支)均较治疗前升高(P<0.05),且治疗组均优于对照组(P<0.05);两组治疗后肌红蛋白、肌酸激酶同工酶、超敏肌钙蛋白T均较治疗前升高(P<0.05),且治疗组均优于对照组(P<0.05);两组全血黏度、血浆黏度、红细胞刚性指数、红细胞聚集指数均较治疗前降低(P<0.05),而红细胞变形指数均较治疗前升高(P<0.05);且治疗组均优于对照组(P<0.05)。结论:丹参多酚酸盐注射液联合PCI术治疗稳定性心绞痛有一定的疗效,能够提高心功能,改善冠脉微循环和血液流变学。Objective： To observe the clinical effect of coronary microcirculation and hemorrheology in patients with stable angina treated with salvianolate injection combined PCI surgery. Methods： Stable angina patients diagnosed in our hospital in recent years were randomly divided into treatment group and control group. The two groups were given PCI surgery. Based on this, the treatment group was given salvianolate injection. After treatment, the myocardial injury markers, coronary microcirculation and hemorheology index changes were observed and the clinical effect was evaluated. Results： The display control rate of the control group was 52.4%, and the total effective rate of the treatment group was 88.1%, which were significantly higher than those of the control group （P〈0.05）, The LVEF LVEDD and IMR （anterior descending branch） of the two groups were significantly improved （P〈0.05）, which of the treatment were significantly higher than those of the control group after treatment （P〈0.05）. The myoglobin, creatine kinase isoenzyme, allergic troponin T of the two groups were significantly improved （P〈0.05）, which of the treatment were significantly lower than those of the control group after treatment （P〈0.05）; The whole blood viscosity, plasma viscosity, erythrocyte rigidity index, erythrocyte aggregation index of the two groups were significantly reduced （P〈0.05）, The erythrocyte deformation index of the two groups were significantly improved （P〈0.05）, which of the treatment was significantly higher than that of the control group after treatment （P〈0.05）. Conclusion： The application of coronary microcirculation and hemorrheology in patients with stable angina treated with salvianolate injection combined PCI surgery can effectively improve cardiac function, perfect the patient＇s coronary microcirculation and blood rheology.

关 键 词：稳定性心绞痛 丹参多酚酸盐注射液 PCI 冠状动脉微循环 血液流变学 

分 类 号：R256.2[医药卫生—中医内科学]