急腹症感染性休克患者病原菌分布及耐药性研究  

Distribution and drug resistance of pathogens isolated from acute abdomen patients with septic shock

作　　者：周峰[1] 晏玉奎[2] 许岚[1] 谈鹰[1] 徐鑫[1] ZHOU Feng YAN Yu-kui XU Lan TAN Ying XU Xin(The Central Hospital of Huzhou, Huzhou, Zhejiang 313000, China)

机构地区：[1]湖州市中心医院急诊科,浙江湖州313000 [2]湖州市中心医院神经内科,浙江湖州313000

出　　处：《中华医院感染学杂志》2017年第5期1082-1084,1088,共4页Chinese Journal of Nosocomiology

基　　金：浙江省医药卫生科技计划基金资助项目(2016ZHB023)

摘　　要：目的研究急腹症感染性休克患者病原菌分布及耐药性,为临床诊治提供参考。方法选取2014年12月-2016年1月医院临床收治的急腹症感染性休克患者55例为研究对象,对患者的病原菌分布及耐药性情况进行调查研究。结果 55例急腹症感染性休克患者共检出病原菌71株,革兰阴性菌52株、革兰阳性菌18株和真菌1株,分别占73.24%、25.35%和1.41%;革兰阴性菌对亚胺培南的敏感度高,耐药率为0.00%,对氨苄西林和哌拉西林的耐药性高,耐药率均为100.00%;革兰阳性菌对万古霉素的敏感度高,耐药率为0.00%,对氨苄西林、哌拉西林和他唑巴坦的耐药性高,耐药率均为100.00%。结论急腹症感染性休克患者的病原菌以革兰阴性菌为主,耐药性普遍较高,临床上应针对药敏结果给予患者针对性的干预和治疗。OBJECTIVE To explore the distribution and drug resistance of pathogens isolated from acute abdomen patients with septic shock so as to provide guidance for clinical diagnosis and treatment. METHODS A total of 55 acute abdomen patients with septic shock who were treated in the hospital from Dec 2014 to Jan 2016 were recruited as the study objects. The distribution and drug resistance of the pathogens isolated from the patients were observed. RESULTS Totally 71 strains of pathogens were isolated from the 55 acute abdomen patients with septic shock, including 52 （73.24 %） strains of gram-negative bacteria, 18 （25.35% ） strains of gram-positive bacteria, and 1 （1.41%） strain of fungus. The gram-negative bacteria were highly susceptible to imipenem, with the drug resistance rate 0.00% the drug resistance rates to ampicillin and piperacillin were 100.00%. The gram-positive bacteria were highly ＂susceptible to vancomycin, with the drug resistance rate 0.00% the drug resistance rates to ampicillin, piperacillin, and tazobactam were 100.00 %. CONCLUSION The gram-negative bacteria are dominant a- mong the pathogens isolated from the acute abdomen patients with septic shock and are highly resistant to antibiot- ics. It is necessary for the hospital to take targeted intervention measures and conduct drug therapy based on the result of drug susceptibility testing.

关 键 词：急腹症 感染性休克 病原菌 耐药性 

分 类 号：R378[医药卫生—病原生物学]