GLP-1类似物蛋白结构及功能研究进展  

Progress on structure and function of GLP-1 analogue

作　　者：常东峰 谢溱[1] 蒋琳[1] 

机构地区：[1]兰州生物制品研究所有限责任公司第四研究室甘肃省疫苗工程技术研究中心,甘肃兰州730046

出　　处：《微生物学免疫学进展》2017年第1期80-86,共7页Progress In Microbiology and Immunology

摘　　要：基于胰高血糖素样肽-1(glucagon-like peptide-1,GLP-1)结构改变得到的GLP-1类似物,能迅速、高效、持久地降低血糖及糖化血红蛋白,具有改善胰岛β细胞功能、调节收缩压、保护心血管、降低血脂、减轻体重、延迟胃排空、增加饱腹感等作用,成为近年来2型糖尿病治疗领域研究的热点。本文对GLP-1及其类似物的结构、功能、不良反应、蛋白质结构研究的方法作一综述。The GLP （Glucagon-like peptide） -1 analogue was modified in structure based on GLP -1 ,which could rapidly, efficiently and lastingly reduce levels of the blood glucose and glycated hemoglobinand had some effects on improving the function of islet/3 cell, regulating systolic pressure, protecting cardiovascular, lowering blood lipids, reducing body weight, de- laying gastric emptying,and increasing satietyetc. So it had become the hot spot in treatment of type 2 diabetes in recent years. This paper reviews the structures, function and adverse reactions on GLP-1 and its analogue, and briefly summarizes the methods used in exploration of protein structure.

关 键 词：胰高血糖素样肽-1 结构 功能 蛋白组学 

分 类 号：R587.1[医药卫生—内分泌]