奥沙西泮与劳拉西泮治疗广泛性焦虑症的对照研究  

Efficacy and Safety of Oxazepam and Lorazepam for Patients with Generalized Anxiety Disorder

作　　者：李艳艳[1] 刘治港 

机构地区：[1]郑州人民医院临床心理科,郑州450003 [2]郑州大学第一附属医院精神医学科,郑州312000

出　　处：《海峡药学》2017年第2期81-83,共3页Strait Pharmaceutical Journal

摘　　要：目的研究奥沙西泮与劳拉西泮治疗广泛性焦虑的临床疗效和安全性。方法回顾性分析广泛性焦虑障碍120例,随机分为两组,奥沙西泮组和劳拉西泮组,各60例,比较两组治疗后的临床疗效,以及评定治疗期间的不良反应发生率。结果奥拉西泮组临床治疗有效率高于劳拉西泮组,差异有统计学意义(P<0.05);两组治疗期间所发生的不良反应比率差异均无统计学意义(P>0.05);奥拉西泮组治疗后肝功能异常低于劳拉西泮组。差异有统计学意义(P<0.05)。结论奥沙西泮治疗广泛性焦虑症,临床疗效优于劳拉西泮,对肝功能影响小,安全性更高。OBJECTIVE To investigate the efficacy and safety of oxazepam and lorazepam for patients with generalized anxiety disorder.METHODS 120 cases of generalized anxiety disorder with ICD-10 diagnosis standard were selected in our hospital,of which were randomly divided into oxazepam group（n=60） and lorazepam group（n=60）,oxazepam group was given Escitalopram Oxalate and lorazepam group was given Escitalopram Oxalate.The clinical curative were compared and the complication occurrence of the two groups were analyzed.RESULTS The effective rate of oxazepam group was 95.0%,and it was higher than iorazepam group（75.0%）（P0.05）.The difference of adverse reactions occurrence from the two groups was no significance（P0.05）.The liver dysfunction rate of oxazepam group was lower than that iorazepam group（P0.05）.CONCLUSION The treatment for generalized anxiety disorder with oxazepam,that the clinical effect of it is better than lorazepam,and it has more suitabie for appiication in the patients with generalized anxiety disorder.

关 键 词：奥沙西泮 劳拉西泮 广泛性焦虑 疗效 安全性 

分 类 号：R969.4[医药卫生—药理学]