新诊断男性2型糖尿病患者血清维生素D与血糖、年龄关系的研究  

Relationship between blood glucose level and vitamin D in newly-diagnosed male T2DM patients

作　　者：宋美潓 高琳[1] 阳琰[1] 张晗[1] 王倩[1] 廖鑫[1] SONG Mei-hui GAO Lin YANG Yan et al(Department of Endocrinology, The Affliated Hospital of Zunyi Medical College, Zunyi 563099, Chin)

机构地区：[1]遵义医学院附属医院内分泌科,563099

出　　处：《中国糖尿病杂志》2017年第3期236-240,共5页Chinese Journal of Diabetes

基　　金：国家自然科学基金(81460168);贵州省社会发展攻关项目[SY(2013)3033]

摘　　要：目的观察新诊断男性T2DM患者血清25羟维生素D[25(OH)D]水平,以及与血糖、年龄的关系。方法选取新诊断男性T2DM患者(T2DM组)240例及健康对照组(NC)80名。T2DM组再根据年龄及HbA_1c分别分组,分析25(OH)D、FPG、FIns、FC-P、TG、TC、HDL-C及LDL-C水平。结果T2DM组25(OH)D低于NC组(P=0.032),维生素D缺乏者比例较NC组升高(P=0.029)。T2DM组中,维生素D缺乏者比例≥60岁亚组,高于<45岁亚组(P=0.041),HbA_1c≥10%亚组高于<7%亚组(P=0.038)。≥60岁亚组及45~60岁亚组25(OH)D、FIns低于<45岁亚组(P=0.021、0.033、0.027、0.031);>60岁亚组FC-P低于<45岁亚组(P=0.042);≥60岁亚组HbA_1c高于<45岁亚组及45~60岁亚组(P=0.031、0.039)。HbA_1c≥10%亚组及HbA_1c 7%~10%亚组FPG高于HbA_1c<7%亚组(P=0.021、0.037),HbA_1c≥10%亚组FPG高于HbA_1c 7%~10%亚组(P=0.028);HbA_1c≥10%亚组FC-P较HbA_1c<7%亚组和HbA_1c 7%~10%亚组降低(P=0.022、0.029);HbA_1c≥10%亚组及HbA_1c7%~10%亚组25(OH)D较HbA_1c<7%亚组降低(P=0.017、0.032)。25(OH)D与HDL-C、FIns呈正相关(r=0.637,P=0.032;r=0.352,P=0.048),与年龄、HbA_1c呈负相关(r=-0.270,P=0.001;r=-0.237,P=0.046)。多元逐步回归分析结果显示,年龄、HbA_1c是25(OH)D的独立影响因素(P=0.003、0.016)。结论 T2DM患者易合并维生素D缺乏,年龄增越大、血糖水平越高,血清维生素D水平越低。Objective To analyze the levels of the serum 25（OH）D in newly-diagnosed type 2diabetes（T2DM）male patients and the relationship with blood glucose and age. Methods 240 male newly-diagnosed T2 DM and 80 healthy men were selected.Serum 25（OH）D levels were detected and the degrees of vitamin D deficiency between different groups of age and HbA1 c were compared. ResultsThe level of serum 25（OH）D in T2 DM group was lower than that in normal group（P=0.032）.The proportion of severe vitamin D deficiency in T2 DM group was higher than that in normal group（P=0.029）.The percentage of vitamin D severe deficiency in patients aged≥60was higher than that in those aged 〈45（P=0.041）.The percentage of vitamin D severe deficiency in subgroup HbA1 c ≥10% was greater than that in subgroup HbA1c〈7%（P=0.038）.The levels of 25（OH）D and FIns in patients aged≥60and 4560were lower than that in those〈45（P=0.021,0.033,0.027 and 0.031,respectively）.The level of FCP in T2 DM patients aged 〉60was lower than that in those〈45（P=0.042）.HbA1 c of T2 DM patients aged ≥60was higher than that of those 〈45and aged 4560（P=0.031 and 0.039）.The levels of FPG in subgroups HbA1c≥10% and 7%10%were higher than that in subgroup HbA1c〈7%（P=0.021,0.037 and 0.028）.FPG of subgroups HbA1c≥10% was higher than that in subgroups HbA1 c 7%10%.FC-P of subgroups HbA1c≥10% was lower than that in subgroups HbA1c〈7%and7%10%（P=0.022 and 0.029）.25（OH）D levels of subgroups HbA1c≥10% and 7% 10% were lower than that in subgroups HbA1c〈7%（P=0.017 and 0.032）.25（OH）D was positively associated with the levels of HDL-C and Fins（r=0.637,P=0.032;r=0.352,P=0.048）,and negatively correlated with age and HbA1c（r=-0.270,P=0.001;r=-0.237,P=0.046）.HbA1 c and age were independent risk factors of serum 25（OH）D（P=0.003 and 0.016）. Conclusion Vitamin D deficiency is common in newly-diagnosed T2 DM male patients,the older age,the higher blood glucose and the more serious Vitamin D de

关 键 词：糖尿病 2型 年龄 男性 25羟维生素D 糖化血红蛋白 

分 类 号：R587.1[医药卫生—内分泌]