代谢综合征及其各组分与骨质疏松性骨折的相关性研究  

Correaltion of Metabolic Syndrome and Its Components with Osteoporotic Fractures

作　　者：曹婷[1] 张巧[1] 时立新[1] 彭年春[1] 张淼[1] 张松[1] 徐淑静[1] 

机构地区：[1]贵州医科大学附属医院内分泌代谢病科,贵州省贵阳市550004

出　　处：《中国全科医学》2017年第8期903-907,共5页Chinese General Practice

基　　金：贵州省科技厅社会攻关计划[黔科合LG字(2011)016号];贵州省优秀科技教育人才省长专项资金项目[黔省专合字(2010)82号]

摘　　要：目的了解贵阳市40岁及以上居民代谢综合征(MS)及其各组分与骨质疏松性骨折的相关性。方法选取2011年贵阳市云岩区参与慢性病调查的40岁及以上人群9 908例为研究对象。采用自制问卷调查受试者信息,包括性别、年龄、生活习惯、既往病史、骨质疏松性骨折史,测量受试者身高、体质量、腰围、血压,检测空腹血糖(FPG)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)水平。结果 9 908例受试者MS患病率为23.87%(2 365/9 908),骨质疏松性骨折史检出率为17.65%(1 749/9 908)。男性受试者中,骨折组与非骨折组年龄、未饮茶、未饮酒、饮牛奶比例、体质指数(BMI)、MS患病率、腰围、收缩压、舒张压以及FPG、TG、HDL-C水平比较,差异均无统计学意义(P>0.05)。女性受试者中骨折组年龄、饮牛奶比例、BMI、MS患病率、腰围、收缩压、TG水平均高于非骨折组,HDL-C水平低于非骨折组(P<0.05)。多因素Logistic回归分析显示,校正年龄、饮茶、饮酒、饮牛奶、BMI等混杂因素后,未发现MS及其各组分与男性受试者骨质疏松性骨折有关(P>0.05),而MS〔OR=1.224,95%CI(1.065,1.407)〕、中心性肥胖〔OR=1.399,95%CI(1.187,1.647)〕、高水平TG〔OR=1.273,95%CI(1.121,1.446)〕、低水平HDL-C〔OR=1.142,95%CI(1.009,1.294)〕是女性受试者发生骨质疏松性骨折的危险因素(P<0.05)。结论 MS及其组分中心性肥胖、血脂异常是40岁及以上女性发生骨质疏松性骨折的危险因素。Objective To explore the association of metabolic syndrome（MS） and its components with osteoporotic fractures in residents aged 40 or over in Guiyang. Methods The subjects enrolled in this study were 9908 residents aged 40 or over in Yunyan district of Guiyang who participated in a survey of chronic diseases in 2011. A self- developed questionnaire was used to survey the subjects,which included gender,age,living habits,medical history and history of osteoporotic fractures. We measured the height,body weight,waist circumference,blood pressure,fasting plasma glucose（FPG）,triglyceride（TG）,high- density lipoprotein cholesterol（HDL-C） levels in the subjects. Results Of the 9908 participants,23.87%（2365/9908） had MS; 17.65%（1749/9908） had a history of osteoporotic fractures. There were no significant differences in age,proportions of residents without drinking tea and wine,ratio of residents drinking milk,BMI,prevalence rate for MS,waist circumference,systolic and diastolic blood pressure,FPG,TG,and HDL-C levels between male with a history of osteoporotic fractures and those without（P〉0.05）. Female with a history of osteoporotic fractures had older age, higher proportion of residents drinking milk,higher BMI and prevalence rate for MS,longer waist circumference,higher systolic pressure and TG,but lower HDL-C than those without（P〈0.05）. Multivariate Logistic regression analysis found that, after adjusting for confounding factors,such as age,drinking tea,wine and milk,and BMI,MS and its components had no relationship with osteoporotic fractures in male participants（P〉0.05）; MS 〔OR=1.224,95% CI（1.065,1.407）〕,central obesity〔OR=1.399,95% CI（1.187,1.647）〕,elevated level of TG 〔OR=1.273,95% CI（1.121,1.446）〕,decreased level of HDL-C 〔OR = 1.142,95% CI（1.009,1.294）〕were significantly associated with increased odds of osteoporotic fractures in female participants（P〈0.05）. Conclusion MS and its components of central obesity and dyslipidemia are risk

关 键 词：骨质疏松症性骨折 代谢综合征X 危险因素 肥胖 腹部 血脂异常 

分 类 号：R683[医药卫生—骨科学]