母亲出生体重与新生儿出生体重的关系研究  

The correlation analysis of maternal birth weight and newborn birth weight

作　　者：李玫[1] 王颖[1] 解冰洁 郭朋鸽[1] 程雁鹏[1] 邬维为 冯永亮[1] 张萍[1] 王素萍[1] 张亚玮[1,2] 杨海澜[3] 

机构地区：[1]山西医科大学公共卫生学院流行病学教研室,山西太原030001 [2]耶鲁大学公共卫生学院环境健康科学系,美国纽黑文ct06410 [3]山西医科大学第一医院妇产科,山西太原03000

出　　处：《中华疾病控制杂志》2017年第3期295-298,307,共5页Chinese Journal of Disease Control & Prevention

基　　金：国家自然科学基金(81473061);山西省青年科技研究基金(2013021033-2);山西省普通高校特色重点学科建设项目(2012年);山西医科大学十人计划项目(2015年)

摘　　要：目的探讨母亲出生体重与新生儿出生体重的关系,以便为研究母亲宫内发育不良对子代发育的影响提供线索。方法通过巢式病例对照研究,采用多重线性回归分析了解母亲出生体重与新生儿出生体重的关系,并以非条件Logistic回归分析进一步探讨母亲出生体重对小于胎龄儿(small for gestational age,SGA)、大于胎龄儿(large for gestational age,LGA)的影响。结果 SGA的发生率为7.04%,LGA发生率为14.65%。多重线性回归分析结果显示,母亲出生体重与新生儿出生体重呈正相关,母亲出生体重每增加1 kg,新生儿出生体重增加174 g(β=0.174,95%CI:0.134~0.213)。随母亲出生体重的增加,SGA发生率递减(χ_(趋势)~2=13.791,P<0.001),LGA的发生率递增(χ_(趋势)~2=7.900,P=0.005),母亲低出生体重(<2 500 g)是SGA的危险因素(OR=2.458,95%CI:1.333~4.534);以孕期增重分层分析后,结论一致,但出生体重较低的孕妇(<2 500 g)孕期增重不足会导致SGA发生风险增高。结论孕妇出生体重低是分娩SGA的危险因素,随着孕妇出生体重增加,新生儿出生体重增大,但未发现LGA与孕妇出生体重有关。Objective To explore the influence of maternal birth weight on newborn birth weight, so as to study whether the mother intrauterine dysplasia affect the growth of children. Methods A nested case-control study and multiple linear regression models were used to explore the relationship of maternal birth weight and newborn birth weight, Logistic regression analysis was performed to evaluate the further influence of maternal birth weight on small for gestational age （SGA） and large for gestational age（LGA）. Results The incidence of SGA and LGA were 7.04% and 14. 65% respectively. The positive association for matermal brith weight remained, getting a result in offspring birth weight by 174 g （ β = 0. 174, 95% CI：0. 134-0. 213） for every 1 000 g rise in maternal birth weight. The incidence of SGA showed a declining trend with maternal birth weight increasing （χ^2trend = 13. 791, P 〈0. 001 ）, and the incidence of LGA increased with maternal birth weight （χ^2trend= 7. 900, P = 0. 005 ） , maternal low birth weight （ 〈 2 500 g） was a risk factor for SGA （ aOR = 2. 458, 95% CI：1. 333-4. 534）. In pregnancy weight gain multilevel Logistic models, the conclusion basically remained unchanged, but the risk rations of SGA in low maternal birth weight among pregnant women who were low weight-gaining during pregnancy were higher than those who were stable weight-gaining. Conclusions Low maternal birth weight is a risk factor for SGA, and newborn birth weight increases with maternal birth weight, but no evidence showed that there is a relationship between maternal birth weight and LGA.

关 键 词：婴儿 小于胎龄 出生体重 宫内发育 

分 类 号：R181.2[医药卫生—流行病学]