基于EQ-5D量表的高血压患者生命质量评价及其用药现状  

Evaluation of health related life quality and clinical medication status in hypertensive patients based on EQ-5D scale

作　　者：边原[1] 冯双[2] 龙恩武[1] 胡明[2] BIAN Yuan FENG Shuang LONG En-wu HU Ming(Department of Pharmacy, Sichuan Academy of Medical Sciences ＆ Sichuan Provincial People＇s Hospital, Chengdu SICHUAN 610072, China West China School of Pharmacy, Sichuan University, Chengdu SICHUAN 610041, China)

机构地区：[1]四川省医学科学院.四川省人民医院药学部,四川成都610072 [2]四川大学华西药学院,四川成都610041

出　　处：《中国新药与临床杂志》2017年第3期166-172,共7页Chinese Journal of New Drugs and Clinical Remedies

基　　金：四川省医学会科研课题(SHD14-10)

摘　　要：目的调查分析高血压患者基本用药情况与生命质量现状及其影响因素,为促进临床合理用药,提高患者生命质量提供参考。方法采用嵌合欧洲五维健康(EQ-5D)量表的自编问卷,纳入意识清楚、自愿参与的非继发性18周岁以上高血压患者,于2016年7月5日至2016年8月30日对成都市部分"三甲"综合医疗机构心血管内科门诊高血压患者的用药情况及生命质量状况进行调查。结果共纳入符合标准的高血压患者562例;问卷统计分析结果表明,被调查高血压患者健康效用值为0.84±0.13,健康效用值视觉模拟(EQ-VAS)评分为(73.42±13.93)分。患者用药类别以二氢吡啶类钙通道阻滞药(CCB)降压药物使用比例最高;二联用药以血管紧张素受体拮抗药(ARB)联合二氢吡啶类CCB比例最高(42.9%),三联用药以二氢吡啶类CCB+ARB+β受体阻滞药占比最高(34.5%);8.0%的二联用药患者联用了同一类药物,1.8%的二联用药患者联合使用了血管紧张素转化酶抑制药和ARB;与男性患者相比,女性患者的EQ-5D指数相对更低。结论临床上应高度关注降压药物的联合应用,尽量避免两种同类降压药物联合应用等不合理用药情况;鉴于抽样的局限,本研究相关结果尚有待大规模临床研究予以证实。AIM To investigate and analyze the basic medication situation, life quality status and its influencing factors in hypertensive patients, so as to provide reference for improving the life quality of the patients and clinical rational drug use. METHODS Using self compiled questionnaire with chimeric EQ- 5D scale, setting inclusion and exclusion criteria, the patients with hypertension who visit the cardiology clinic of the ＂three grade＂ integrated medical institutions in Chengdu City were investigated during July 5, 2016 to August 30, 2016, in which the information of medication situation and the life quality status of the patients were collected. RESULTS A total of 562 hypertensive patients met criterion were included. Statistical analysis results showed that the health utility value of the patients was 0.84 ± 0.13, EQ-VAS score was （73.42 ± 13.93） points. The patients medication categories were majority in dihydropyridine calcium antagonists （CCB） ; in combination with two drugs, the highest proportion （42.9%） was angiotensin receptor antagonists （ARB） combined with CCB; 8.0% of the patients had used same class of drugs combination; and 1.8% of the patients had combined with angiotensin converting enzyme inhibitors and ARB. In combination with three drugs, CCB and ARB combined with beta receptor blockers was in the highest proportion （34.5%）. Compared with the male patients, EQ-5D index of the female was relatively lower. CONCLUSION Clinician should pay high attention to the combined use of antihypertensive drugs for the patients with hypertension, try to avoid the combination medication of same classes of two antihypertensive drugs. In view of the sample limitations, the results of this study need to be confirmed in large clinical research.

关 键 词：高血压 生命质量 EQ-5D 抗高血压药 健康调查 

分 类 号：R969.3[医药卫生—药理学]