大肠杆菌K1侵袭血脑屏障的研究进展  

Research Advances in Escherichia coli K1 Penetration Across Blood-brain Barrier

作　　者：凌晨[1] 张奇文[1] 宋康[2] 蒋建军[1] 剡根强[1] LING Chen ZHANG Qi-wen SONG Kang JIANG Jian-jun YAN Gen-qiang(College of Animal Science and Technology , Shihezi University, Shihezi 832000, China The General Station of Animal Husbandry and Veterinary Medicine of Division No. 13 of Xinjiang Production and Construction Corps, Hami 839000, China)

机构地区：[1]石河子大学动物科技学院,石河子832000 [2]新疆生产建设兵团第十三师畜牧兽医工作站,哈密839000

出　　处：《中国畜牧兽医》2017年第3期686-691,共6页China Animal Husbandry & Veterinary Medicine

基　　金：国家科技支撑计划(2012BAD43B02)

摘　　要：大肠杆菌K1株是引起新生儿败血症和脑膜炎的代表菌株,经血液循环进入大脑而致病。大肠杆菌K1黏附、侵袭脑微血管内皮细胞(BMECs)并穿越血脑屏障(BBB)的分子机制一直是众多学者研究探讨的热点。文章重点阐述致脑膜炎大肠杆菌K1穿越BBB的基因调控和信号介导通路,旨在了解致脑膜炎大肠杆菌感染的分子机理,为预防和治疗脑膜炎提供参考。E.coli K1 strain is a representative strain of neonatal sepsis and meningitis,which causes disease by blood circulation to the brain.The molecular mechanism of E.coli K1 that adhering and invading the brain microvascular endothelial cells（BMECs）and cross the blood brain barrier（BBB）has been focused on by many scholars.In this review,we focused on the gene regulation mechanisms and signaling pathway of E.coli K1 crossing the blood brain barrier to understand the molecular mechanism of the infection caused by E.coli and provide reference for prevention and treatment programs.

关 键 词：大肠杆菌 脑膜炎 侵袭 人脑微血管内皮细胞 血脑屏障 

分 类 号：R378.21[医药卫生—病原生物学]