脂肪酸对动物骨骼肌的代谢调控作用  

The Metabolic Regulatory Effect of Fatty Acids on Mammal Skeletal Muscle

作　　者：王乐山[1] 左旭冬 江青艳[1] 王丽娜[1] WANG Le-shan ZUO Xu-dong JIANG Qing-yan WANG Li-na(College of Animal Science, South China Agricultural University, Guangzhou 510642, China)

机构地区：[1]华南农业大学动物科学学院,广州510642

出　　处：《中国畜牧兽医》2017年第3期748-754,共7页China Animal Husbandry & Veterinary Medicine

基　　金：国家重点基础研究发展计划(2012CB124701)

摘　　要：传统观点认为,脂肪酸的主要作用是给细胞供能。最近研究显示,脂肪酸对细胞的生长发育和代谢都有调控作用。骨骼肌作为脂肪酸代谢的重要场所,是脂肪酸发挥调控作用的主要靶标。棕榈酸与骨骼肌胰岛素抵抗(IR)密切相关;油酸通过过氧化物酶体增殖体活化受体促进脂肪酸的氧化和甘油三酯的合成;亚麻酸可通过促进葡萄糖的利用,缓解骨骼肌的胰岛素抵抗;共轭亚油酸(CLA)通过多条信号通路影响骨骼肌的代谢活动;二十二碳六烯酸(DHA)和花生四烯酸(ARA)能显著改变骨骼肌肌球蛋白重链的基因表达;二十碳五烯酸(EPA)对骨骼肌的糖代谢、线粒体活动和Apelin系统都有一定影响。作者通过对不同脂肪酸对骨骼肌的调控作用进行探讨,试图揭示不同脂肪酸的差异化调控机制,从而为开发脂肪酸产品提供一定的理论依据。Fatty acids are thought to supply energy for cell traditionally.Recent studies have shown the effect of fatty acids on cellular growth,development and metabolism.Skeletal muscle is an important place for fatty acids consumption,and it＇s also the main target where fatty acids play its role.Palmitic acid is closely related to skeletal muscle insulin resistance（IR）;Oleic acid can increase skeletal muscle fatty acids oxidation and triglyceride synthesis through peroxisome proliferator activated receptor;Linolenic acid relieves skeletal muscle insulin resistance by increasing glucose utilization;Conjugated linoleic acid（CLA）influences skeletal muscle metabolismvia multiple signal passways;Docosahexaenoic acid（DHA）and arachidonic acid（ARA）can significantly change myosine heavy chain gene expression;Eicosapntemacnioc acid（EPA）has some effect on skeletal muscle glucose metabolism,mitochondrial action and Apelin system.This review focuses on the effects of different fatty acids on skeletal muscle.And we will have a better understanding about the diverse regulatory mechanism of various fatty acids,and we also hope that this paper will provide some theoretical foundations for the research and development of fatty acids products.

关 键 词：脂肪酸 骨骼肌 胰岛素 线粒体 

分 类 号：Q547[生物学—生物化学]