药物性肝损伤机制的研究进展  

Research advances in the mechanism of drug-induced liver injury

作　　者：张守堂[1] 万国靖[1] 李璐[1] ZHANG ShouTang WAN GuoJing LI Lu(Department of Pharmacy, General Hospital of Armed Police of Heilongjiang Province, Harbin 150076,China)

机构地区：[1]武警黑龙江省总队医院药剂科,哈尔滨150076

出　　处：《药学服务与研究》2017年第1期39-42,共4页Pharmaceutical Care and Research

摘　　要：药物性肝损伤(drug-induced liver injury,DILI)属于药品不良反应之一,每年的发生率都呈急速上升的趋势,已经成为临床上需要面临的主要严重疾病之一。由于DILI的临床表现多样,缺乏特异性,隐匿性强,危害大,目前尚无统一的临床诊断标准,常导致漏诊和误诊。本文分析总结了药物性肝损伤的发病机制,对于临床及时准确诊断和防治药物性肝损伤具有重要意义。Drug-induced liver injury（DILI）is one of adverse drug reactions.The incidence of DILI showed a rapid upward trend each year.It has become one of the major severe diseases that clinical physicians are to be faced with.Due to the diversity of clinical manifestations,lack of specificity and uniform diagnosis criteria for DILI,missed diagnosis and misdiagnosis often occured clinically.This paper summarized the pathogenesis of DILI and was of clinical importance for timely and accurate diagnosis,prevention and treatment of DIL.

关 键 词：药物性肝损伤 发生机制 诊断 综述 

分 类 号：R994.11[医药卫生—毒理学]