高脂血症性急性胰腺炎的临床特征研究  

作　　者：于费杰[1] 闵捷[1] 赵凤庆[1] 吴晓俊[1] 周俊[1] 

机构地区：[1]浙江省嘉兴市第一医院肝胆外科,314001

出　　处：《浙江临床医学》2017年第4期686-687,689,共3页Zhejiang Clinical Medical Journal

摘　　要：目的对比研究高脂血症性急性胰腺炎（HLAP）与非高脂血症性急性胰腺炎（NHLAP）的临床特征，以提高对HLAP的认识。方法选取2010年1月至2015年12月期间进行治疗的急性胰腺炎（AP）患者231例，根据病因分为HLAP组及NHLAP组，比较两组患者的临床资料、主要生化指标、影像学资料、并发症率、病死率及复发率等方面资料。结果HLAP组患者的总胆固醇、TG、血糖、C反应蛋白（CRP）均高于NHLAP组患者，而HLAP组患者的血清淀粉酶、丙氨酸氨基转肽酶（ALT）和总胆红素均低于NHLAP组患者。HLAP组患者在Ranson评分≥3分例数、全身炎症反应综合征（SIRS）例数及CTSI评分高于NHLAP组。HLAP组患者的复发率、SAP、胰腺坏死、呼吸衰竭的发生率高于NHLAP组患者。结论HLAP与NHLAP比较，具有明显不同的临床特征，HLAP病情重，复发率高，而血清淀粉酶升高水平低。Objective To compare the clinical features of hyperlipidemic acute pancreatitis （ HLAP ） and non-hyperlipidemic acute pancreatitis （ NHLAP ） , and improve the recognition of HLAP. Methods The medical records of 231 patients with acute pancreatitis who were admired to our hospital from January 2010 to December 2015 were reviewed.The patients were divided into HLAP group and NHLAP group according to the pathogeny. The general clinical data, main biochemical index, imaging data, complications, mortality and recurrence rate between two groups were compared. Results The serum levels of total cholesterol, TG, blood glucose and CRP in HLAP group were higher than those in NHLAP group, while the levels of amylase, ALT and total bilirubin in HLAP group were lower than those in NHLAP group. Compared with NHLAP group, the paitents with HLAP were more likely to have a higher frenquency of Ranson scores ≥3 and developed SIRS, also had higher CTSI scores. Higher incidences of recurrence rate, SAP, pancreastic necrosis and respireatory failure were also observed in patients with HLAP. Conclusion The clinical features of HLAP are different from NHLAP, the HLAP is more severe, with high recurrence rate, and make low level of serum amylase.

关 键 词：胰腺炎 高脂血症 临床特征 

分 类 号：R589.2[医药卫生—内分泌]