阿替普酶静脉溶栓时间窗选择对急性脑梗死患者疗效影响  

The Efficacy of Intravenous Thrombolysis by Alteplase in Acute Cerebral Ischemic Stroke Within Different Time Windows

作　　者：李晓慧[1] 魏明阳[1] 鹿梁燕[1] 张建斌[1] LI Xiaohui WEI Mingyang LU Liangyan ZHANG Jianbin(Neurological Rehabilitation Department, Affiliated Heji Hospital of Changzhi Medical College, Changzhi Shanxi 046000, Chin)

机构地区：[1]山西长治医学院附属和济医院神经康复科,山西长治046000

出　　处：《中国卫生标准管理》2017年第4期70-72,共3页China Health Standard Management

摘　　要：目的探究不同时间窗内选择阿替普酶静脉溶栓对急性脑梗死(ACI)患者疗效的影响。方法选取2013年6月—2016年6月入我院行阿替普酶静脉溶栓治疗的急性脑梗死患者38例,分为3组:A组(时间窗<3 h,12例);B组(时间窗为3~4.5 h,16例);C组(时间窗为4.5~6 h,10例)。均予以阿替普酶溶栓治疗,统计溶栓后3组患者的NIHSS评分,比较疗效和不良反应发生率。结果总有效率A组高于C组,差异有统计学意义(P<0.05)。不良反应差异无统计学意义(P>0.05)。结论发病6 h内阿替普酶静脉溶栓对急性脑梗死疗效显著,有较高安全性,溶栓时间越早疗效越佳。Objective To investigate the efficacy of intravenous thrombolysis by alteplase in ACI within different time windows.Methods 38 cases of ACI patients were divided into three groups according to the time window：the A group（time window3 h,12 cases）,the B group（time window 3~4.5 h,16 cases）,the C group（time window 4.5~6 h,10 cases）.The NIHSS,crative effect and adverse events in the three groups were statistical.Results The total effective rate in the A group were obvious higher than the C group（P〈0.05）;the adverse events incidence rate were not statistically significant（P〉0.05）.Conclusion The curative effect is remarkable and excellently safe for intravenous thrombolysis by alteplase in ACI within 6 h time window,and the earlier is thrombolytic therapy,the curative effect is better.

关 键 词：急性脑梗死 溶栓 阿替普酶 时间窗 

分 类 号：R971[医药卫生—药品]