妊娠期糖尿病危险因素分析及患者血清RBP4、leptin、Nesfatin-1水平变化  

Risk factors and changes of serum RBP4,leptin,Nesfatin-1 levels in patients with Gestational diabetes mellitus

作　　者：徐菁 

机构地区：[1]广州市黄埔区中医医院妇产科,广东广州510700

出　　处：《中国实验诊断学》2017年第3期448-451,共4页Chinese Journal of Laboratory Diagnosis

摘　　要：目的探讨妊娠糖尿病(GDM)发生的危险因素及患者血清视黄醇结合蛋白4(RBP4)、瘦素(leptin)、人新饱食分子蛋白-1(Nesfatin-1)水平表达。方法选取2013年5月至2015年7月我院收治的50例妊娠糖尿病患者为观察组和210例健康妊娠妇女为对照组,对GDM发生的危险因素进行分析,研究GDM对围生期并发症的影响及患者血清RBP4、leptin、Nesfatin-1水平表达。结果年龄≥27岁、体重指数≥23、有糖尿病家族史、有高血脂、高血压病的孕妇GDM发病率明显高于年龄<27岁、体重指数<23、无糖尿病家族史、无高血脂及高血压病的孕妇,差异具有显著性(P<0.05)。观察组孕妇羊水异常、胎膜早破、早产以及剖宫产率均明显高于对照组(P<0.05);两组血清RBP4、leptin及Nesfatin-1水平比较,观察组显著高于对照组(P<0.05)。结论年龄≥27岁、高体重指数、糖尿病家族史、高血脂以及高血压是GDM发生的危险因素,GDM易导致羊水异常、胎膜早破、早产以及剖宫产等围生期并发症,对血清RBP4、leptin及Nesfatin-1进行检测有助于妊娠糖尿病的诊断。Objective To explore the risk factor and changes of retinol binding protein 4（RBP4）,leptin,Nesfatin-1levels in patients with gestational diabetes mellitus（GDM）.Methods 50 patients with GDM were enrolled as observation group and 210 healthy pregnant women as control group.The risk factors of GDM were analyzed.The complications in perinatal period and serum RBP4,leptin,Nesfatin-1levels in patients with GDM were studied.Results The morbidity of GDM in pregnant women more than 27 years old,body mass index larger than 23,combined with diabetic family history,hyperlipidemia and hypertension were higher than patients less than 27 years old,body mass index smaller than 23,without diabetic family history,hyperlipidemia and hypertension（P〈0.05）.The complication rates of abnormal amniotic fluid,premature rupture of membranes,premature birth and cesarean delivery in observation group were significantly higher than those in control group（P〈0.05）.As for serum RBP4,leptin,Nesfatin-1levels,the observation group were significantly higher than control group（P〈0.05）.Conclusion More than 27 years old,larger body mass index,diabetic family history,hyperlipidemia and hypertension are the risk factors of GDM.Patients with GDM tend to get complications of abnormal amniotic fluid,premature rupture of membranes,premature birth and cesarean delivery.Serum RBP4,leptin,Nesfatin-1can be used for diagnosis of GDM.

关 键 词：妊娠糖尿病 危险因素 并发症 视黄醇结合蛋白4 瘦素 人新饱食分子蛋白-1 

分 类 号：R714.256[医药卫生—妇产科学]