胎儿颈项透明层厚度对筛查胎儿异常的临床价值  

The application value of fetal nuchaltranslucency(NT)obtatained in first trimesterindetecting fetal deformities

作　　者：何顺安[1] 肖燕[1] 魏玲[1] 李江涛[1] 杨淑莉[2] 

机构地区：[1]深圳市南山区妇幼保健院,广东深圳518000 [2]吉林大学第二医院妇产科

出　　处：《中国实验诊断学》2017年第3期458-460,共3页Chinese Journal of Laboratory Diagnosis

摘　　要：目的探讨胎儿颈项透明层厚度(NT)超声检测对筛查胎儿异常的临床价值。方法 2013年3月至2015年3月我院产科门诊接受NT筛查病例2368例,将46例NT值≥3mm病例进行随访,11例胎儿出生后随访至1岁,对不同NT厚度与胎儿出生后的妊娠结局进行分析。结果 2368例NT测量病例中,46例NT增厚,占1.9%,成功随访38例,随访成功率82.6%。27例终止妊娠,原因包括:染色体异常、先天性心脏病、重型地贫及胎儿畸形。5例先天异常儿(2例先天性心脏病、2例消化道畸形及1例唇裂)及6例染色体及结构正常儿足月分娩,正常分娩率28.8%。5例先天异常儿出生后手术治疗,2例消化道异常儿手术后死亡,1例心脏病术后患儿体重低于同龄标准体重第十个百分位数,且智力及运动发育均落后。其他患儿及6例染色体正常无畸形儿出生后生长发育正常。结论 NT增厚与不良临床结局密切相关,随着NT增厚程度的增加,胎儿正常分娩率显著降低。Objective To evaluate the application value of fetal nuchal translucency（NT）obtained in first trimester with ultrasound in detecting fetal deformities.Methods A total of 2368 fetuses were selected which accepted NT thickness between March 2013 and March 2015 in our department.The 46NT≥3mm fetuses were followed up,the fetus were followed up to 1year to detect the results and analyze the relationship between NT thickness and pregnant outcome.Results There were 46（1.9%）cases detected with increased NT.Of all above cases,38（82.6%）were successful followed up.In 38 informed cases,27 were terminated due to following reasons：chromosomal abnormality,congenital heart disease,severe thalassemia,and other structure abnormities.5congenital abnormality fetus and 6normal fetus were delivery.The babies were cured by operation.2babies with the digestive tract abnormalities were died after operation.1baby with congenital heart disease was mental retardation and development delayed.Other babies were normal during following up.Conclusion Increased NT has close relationship with poor pregnant outcome.When NT thickness is higher,the pregnancy outcome is very poor.

关 键 词：颈项透明层厚度 胎儿筛查 超声 

分 类 号：R714.5[医药卫生—妇产科学] R445.1[医药卫生—临床医学]