长链非编码RNA在骨发育中作用的研究进展  

Research progress of the roles of lncRNAs in bone development

作　　者：魏玉[1] 孙瑶[1] WEI Yu SUN Yao.(Department of Oral Implantology,Laboratory of Oral Biomedical Science and Translational Medicine, College of Sto- matology, Tongji University, Shanghai 200072, Chin)

机构地区：[1]同济大学口腔医学院,同济大学附属口腔医院口腔种植科,口腔生物医学及转化医学实验室,上海200072

出　　处：《口腔医学》2017年第3期271-275,共5页Stomatology

基　　金：国家重点研发计划课题(2016YFC11020);高等学校博士学科专项科研基金(20130072120024);上海市卫生和计划生育委员会科研课题(XYQ2013080);国家自然基金(81470715)

摘　　要：长链非编码RNA(Long non-coding RNAs,lncRNAs)是指长度大于200 nt、缺少开放阅读框(ORFs)的非编码RNA,其占非编码RNA的很大比例。长链非编码RNA在表观遗传、转录、翻译以及蛋白质修饰过程中发挥重要的调控作用,从而广泛地参与包括细胞分化、个体发育等在内的重要生命过程。同时越来越多的研究发现它也与人类某些重要疾病发生和发展密切相关。该文综述了lncRNAs在骨发育中的作用。Long non-coding RNAs（ lncRNAs） refer to the non-coding RNAs which exceed 200 nt in length and lack open reading frames,and they account for a significant proportion of non-coding RNAs. LncRNAs play an important role in regulating the process of epigenetics,transcription,translation and protein modification,thus they widely participate in some important life processes including cell differentiation,individual development and so on. At the same time,more and more studies have found that lncRNAs are also closely related to the occurrence and development of some important human diseases. In this paper,the roles of lncRNAs in bone development will be reviewed.

关 键 词：长链非编码RNA 骨发育 骨疾病 

分 类 号：Q522[生物学—生物化学]