孕期高危型HPV感染与子痫前期的相关性分析  

Analysis of the correlation between high-risk HPV infection and preeclampsia during pregnancy

作　　者：温海燕 李晓红 WEN Haiyan LI Xiaohong(Department of Obstetrics,Hangzhou Women＇s Hospital in Zhejing Province,Hangzhou 310000,China Depart- ment of Obstetrics, Rui＇ an Women and Children＇ s Hospital in Zhejiang Province, Rui＇ an 325200, China)

机构地区：[1]杭州市妇产科医院产科,浙江杭州310000 [2]浙江省瑞安市妇幼保健院产科,浙江瑞安325200

出　　处：《中国现代医生》2017年第4期62-64,67,共4页China Modern Doctor

基　　金：温州市第二期科技计划项目(Y20140347)

摘　　要：目的 研究并分析孕期高危型HPV感染与子痫前期的相关性。方法选取2014年3月~2016年2月来我院就诊的子痫前期孕妇102例设为观察组,另取同期正常妊娠孕妇102例设为对照组。比较两组高危型HPV感染发生情况以及血清IL-2、IL-10水平。同时,比较观察组不同高危型HPV感染孕妇的血清IL-2、IL-10水平,并进行相关性分析。结果观察组孕妇高危型HPV感染阳性率为47.06%(48/102),显著高于对照组的9.80%(10/102),差异有统计学意义(P<0.05)。观察组血清IL-2水平显著高于对照组,而IL-10水平显著低于对照组,差异均有统计学意义(P<0.05)。高危型HPV感染阳性组孕妇血清IL-2水平显著高于阴性组,而IL-10水平显著低于阴性组,差异均有统计学意义(P<0.05)。经Spearman相关性分析可知,孕期高危型HPV感染与子痫前期存在显著正相关关系(r=0.572,P=0.014)。结论孕期高危型HPV感染与子痫前期存在显著正相关关系,临床工作中可通过预防高危型HPV感染,以降低子痫前期的发生率。Objective To study and analyze the correlation between high-risk HPV infection and preeclampsia during pregnancy. Methods A total of 102 pregnant women with preeelampsia who were diagnosed in our hospital from March 2014 to February 2016 were assigned to the observation group. Another 102 cases of normal pregnant women in the same period were assigned to the control group. The incidence of high-risk HPV infection and serum IL-2 and IL-10 levels were compared between the two groups. Meanwhile,the levels of serum IL-2 and IL-10 in the pregnant women with different high-risk HPV infections were compared in the observation group,and correlation analysis was per- formed. Results The positive rate of high-risk HPV infection in the observation group was 47.06% （48/102）,which was significantly higher than that in the control group [9.80% （10/102）]. The difference was statistically significant （P〈 0.05）. The level of serum IL-2 in the observation group was significantly higher than that in the control group,while the level of IL-10 in the observation group was significantly lower than that in the control group. The differences were both statistically significant（P〈0.05）. The level of serum IL-2 in the patients with positive high-risk HPV infection was significantly higher than that in the negative group,and the level of IL-10 was significantly lower than that in the negative group. The differences were both statistically significant（P〈0.05）. The spearman correlation analysis showed that there was a significant positive correlation between high-risk HPV infection and preeclampsia during pregnancy（r= 0.572,P=0.014）. Conclusion There is a significant positive correlation between high-risk HPV infection and preeclampsia during pregnancy. High-risk HPV infection can be prevented in clinical works,so as to reduce the inci- dence of preeclampsia.

关 键 词：高危型HPV 子痫前期 孕妇 白细胞介素-2 白细胞介素-10 

分 类 号：R714[医药卫生—妇产科学]