周剂量紫杉醇对不宜手术的局部晚期食管癌患者放疗增敏作用研究  

Radiosensitizing Effect of Weekly-dose Paclitaxel on Locally Advanced Esophageal Carcinoma Patients with not Suitable for Surgery

作　　者：成拯[1] CHENG Zheng.(Affiliated Cancer Hospital ＆ Institute of Guangzhou Medical University, Gnangzhou 510000, China)

机构地区：[1]广州医科大学附属肿瘤医院,广东广州510000

出　　处：《中国医学创新》2017年第8期28-31,共4页Medical Innovation of China

摘　　要：目的:研究周剂量紫杉醇对不宜手术的局部晚期食管癌患者放疗增敏作用。方法:2011年1月-2014年1月,选择于本院接受治疗的不宜手术的局部晚期食管癌患者64例,根据抽签方法随机划分为两组,给予对照组32例患者单纯放疗治疗,给予治疗组32例患者放疗+周剂量紫杉醇治疗,比较两组的疗效、毒副反应的差异。结果:治疗组的近期临床总有效率为90.63%,较对照组68.75%明显升高(P<0.05);治疗期间,毒副反应多为0~Ⅱ度,Ⅲ度较为少见,无Ⅳ度毒副反应,治疗组的毒副反应发生率稍高于对照组,但差异无统计学意义(P>0.05);随访1~3年,治疗组的1、2、3年生存率及局部控制率较对照组均明显升高(P<0.05),随访1~2年,治疗组的卡氏评分较对照组明显升高(P<0.05),但随访3年对比差异无统计学意义(P>0.05)。结论:周剂量紫杉醇可增加不宜手术局部晚期食管癌患者的放疗增敏作用,且未见毒副反应明显增加。Objective： To study the radiosensitizing effect of weekly-dose Paelitaxel on locally advanced esophageal carcinoma patients with not suitable for surgery.Method： From January 2011 to January 2014, 64 cases of locally advanced esophageal carcinoma patients with not suitable for surgery were treated in our hospital and divided into two groups according to the random lottery method, 32 cases of the control group received radiotherapy alone, 32 cases of the treatment group received radiotherapy＋weekly-dose Paclitaxel, the efficacy and side effects of two groups were compared.Result： The clinical total effective rate of the treatment group was 90.63%, higher than 68.75% of the control group （ P〈0.05 ） .During the treatment, the side effects were more than 0 to Ⅱ degrees, Ⅲ degree was rare, and there was no toxic reaction to Ⅳ degree, the incidence of side effects of the treatment group was slightly higher than that of the control group, but there was no statistical significance （ P〉0.05 ） .During the follow-up period of 1-3 years, 1, 2 and 3 years survival rate and local control rate of the treatment group were significantly higher than those of the control group （ P〈0.05 ）, after 1 and 2 years of follow-up, KPS scores of the treatment group were significantly higher than those of the control group （ P〈0.05 ）, but there was no significant difference between two groups after 3 years of follow-up （ P〉0.05 ） .Conclusion： Weekly-dose Paclitaxel can increase the sensitizing effect of radiotherapy on patients locally advanced esophageal cancer with not suitable for surgery, and no obvious side effects are observed.

关 键 词：局部晚期食管癌 周剂量 紫杉醇 放疗 增敏作用 

分 类 号：R735.1[医药卫生—肿瘤]