血清铁蛋白水平与成人系统性红斑狼疮疾病活动的关系  

Relationship between serum ferritin and disease activity of adult systemic lupus erythematosus

作　　者：李纳[1] 阎磊[1] 张丽娜[1] 王丽姣[1] 董洋[1] 邵凤民[1] 

机构地区：[1]郑州大学人民医院(河南省人民医院)肾病风湿免疫科,河南郑州450003

出　　处：《中国老年学杂志》2017年第6期1474-1476,共3页Chinese Journal of Gerontology

基　　金：国家自然科学基金计划项目(81650004);河南省重点科技攻关计划项目(102102310086);河南省重大科技攻关项目(121100910600)

摘　　要：目的探讨成人系统性红斑狼疮(SLE)患者疾病活动度与血清铁蛋白(SF)的关系。方法初次确诊为SLE的患者40例依据SLE疾病活动指数(SLEDAI)评分分为稳定组与活动组。同期确诊为其他自身免疫性疾病的患者38例纳入其他对照组,40例健康体检者纳入正常对照组。电化学发光法检测SF水平,酶联免疫吸附(ELISA)法检测抗ds DNA抗体,同时回顾性收集SLE患者C反应蛋白(CRP)、红细胞沉降率(ESR)、补体及尿蛋白等实验室检查结果。结果 SLE患者SF水平高于其他对照组和正常对照组(P<0.05),且活动组SF水平高于稳定组(P=0.044)。SLE患者SF与SLEDAI评分(r=0.48,P<0.05)、抗ds DNA(r=0.34,P<0.05)、补体C3(r=-0.367,P=0.02)、C4(r=-0.371,P=0.018)均有相关性。另发现尿蛋白阳性的SLE患者SF水平较尿蛋白阴性者高(P<0.001)。结论 SF与SLE疾病活动密切相关,与SLEDAI评分、抗ds NDA抗体滴度及补体C3、C4等指标联合检测可判断成人SLE疾病活动程度,并指导临床治疗。Objective To explore the relationship between disease activity and serum ferritin （SF） in adult systemic lupus erythe- matosus （SLE）. Methods 40 newly diagnosed SLE patients were selected and divided into stable and active groups according to the SLE- DAI score. 38 patients with other autoimmunity diseases （other than SLE ） , and 40 health persons in the same period were also included. The SF level was measured by electrochemiluminescencejavascript： ;, anti-dsDNA was measured by ELISA, and other laboratory indexes of SLE patients such as C reactive protein, erythrocyte sedimentation rate, were collected retrospectively. The data were analyzed. Results The SF level of SLE patients was significantly higher than that of the other control group （ P = 0.011 ） and normal control group （ P〈0. 001 ）. The SF level of active group was significantly higher than that of stable group （568.19±552.01 vs 271.92±268.02 ,P=O. 044）. There was a significant positive correlation of elevated SF levels with SLEDAI score （ r = 0.48, P = 0. 002 ）, and anti-dsDNA （ r = 0.34, P = 0. 032 ） , whereas a negative correlation with complement C3 （r = -0.367,P= 0.02） and C4 （ r = -0. 371,P = 0.018） in SLE patients. In addition, the level of SF in SLE patients with positive urine protein was significantly higher than that of negative urine protein patients （ P〈O. 001 ）. Conclusions SF level is closely related with disease activity of SLE. SF combined with SLEDAI score, anti-dsDNA, complement C3 and C4 can be used to assess the activity of adult SLE patients and guide clinical treatment.

关 键 词：血清铁蛋白 系统性红斑狼疮 疾病活动度 自身免疫性疾病 

分 类 号：R395[哲学宗教—心理学]