环丙沙星柱撑水滑石新型缓释药物的插层组装及性能  

Preparation and Properties of a New Sustained-release Antibiotic Drug Ciprofloxacin Pillared Hydrotalcite

作　　者：刘翠娟[1] 慎爱民[1] 祝红兵[1] 张义秀[1] 赵岩[1] 吕玉光[1] 

机构地区：[1]佳木斯大学药学院生物药制剂黑龙江省重点实验室,黑龙江佳木斯154007

出　　处：《广东化工》2017年第5期38-40,共3页Guangdong Chemical Industry

基　　金：黑龙江省教育厅项目基金(批准号12531693)资助

摘　　要：采用共沉淀法和离子交换法将环丙沙星药物阴离子插层组装到水滑石层间,制备了一种新型缓释性能良好的环丙沙星柱撑水滑石抗菌素药物。通过XRD、FT/IR、SEM对产物分析表征,在模拟人体生理体液不同pH条件下对其体外释放性能进行了研究。A new sustained-release antibiotic drug involving ciprofloxacin（CIP） anions intercalated layered double hydrotalcites was assembled with coprecipitation and ion-exchange methods. The structures of materials were characterized by powder X-ray diffraction, FT-IR spectra and scanning electron microscope. And the in vitro release properties in different pH value were studied.

关 键 词：环丙沙星 水滑石 体外释放 

分 类 号：O614[理学—无机化学]